The main drug for the prevention of "cytokine storm" is low-molecular weight heparin
enoxaparin sodium (Enixum®) in therapeutic doses. We use this drug for all patients who have
SpO2 ≤ 93% (with COPD SpO2 ≤ 84%) without oxygen subsidies.... ///Effective treatment regimen Famotidine with low molecular weight heparin (sodium enoxaparin) severe stages patients COVID-19... Using the treatment regimen enoxaparin sodium + Famotidine, it is possible to treat patients with COVID-19 in an outpatient setting and prevent hospitalization in hospitals...
Introduction
The low molecular weight guanyl-preferring ribonuclease
(RNase) secreted by Bacillus pumilus is known due to its
biological activity including antiviral and antitumor effects
[1–5].... The immutability of binase secondary structure upon transition from low to high protein concentration was registered, suggesting the binase dimerization immediately after translocation through the cell membrane and leading to detection of binase dimers...
Bacillus spp. are known to produce another type of
extracellular RNase with high molecular weight (∼30 kDa)
and low level of catalytic activity, while lacking specificity
towards guanyl residues.... New RNase with a high degree of structural similarity with binase (73%) and barnase (74%) was isolated and purified from Bacillus licheniformis (balifase, calculated molecular weight 12421.9 Da, pI 8.91)....
Western blot analysis found
hACE2 with a molecular weight of approximately
120 kDa, indicating proper protein glycosylation....
One of the well-
studied bacterial RNases is binase, the guanyl-preferring low
molecular weight RNase secreted by Bacillus pumilus [7]....
Probably,
polymucosaccharide chains, in particular hyaluronic
acid derivatives with molecular weights of 5‒15 mil-
lion Da, form hydrophilic shells around the particles.
This results in separation of the contaminant from the
surface....
Intestinal barrier function: molecular regulation and disease pathogenesis. J. Allergy Clin. Immunol.
124, 3–20 (2009).
7. Aijaz, S., Balda, M. S. & Matter, K. Tight junctions: molecular architecture and function. Int. Rev.... There is limited data on the mechanisms of the intestinal barrier disruption upon low-grade inflammation characteristic of patients with inflammatory bowel disease in clinical remission....
No high-molecular weight aggregates or particulate structures were detected by the electron microscopy of purified protein samples....
Current
widely available therapeutic intervention in this regard is
administration of low molecular weight heparin (LMWH)
at prophylactic dose.... Low molecular weight heparin (LMWH) should be administered to all patients with diagnosed COVID-19 infection (including non-critical patients) requiring hospitalization, but having no contraindications to LMWH. © 2020 Moscow Polytechnic University....
This result waives the objection to the
administration of gNO or low-molecular-weight
DNICs with thiol-containing ligands to COVID-19
patients in order to relieve the disease.... In tests on rats that inhaled sprayed aqueous solutions of dinitrosyl iron complexes, their tolerance dose was approximately 0.4 mmol/kg body weight....
