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Статья
Live Attenuated Influenza Vaccines engineered to express the nucleoprotein of a recent isolate stimulate human influenza CD8+ T cells more relevant to current infections
2021
Live attenuated influenza vaccines (LAIV) induce CD8+ T lymphocyte responses that play an important role in killing virus-infected cells. Despite the relative conservation of internal influenza A proteins, the epitopes recognized by T cells can undergo drift under immune pressure. The internal proteins of Russian LAIVs are derived from the master donor virus A/Leningrad/134/17/57 (Len/17) isolated 60 years ago and as such, some CD8+ T cell epitopes may vary between the vaccine and circulating wild-type strains. To partially overcome this issue, the nucleoprotein (NP) gene of wild-type virus can be incorporated into LAIV reassortant virus, along with the HA and NA genes. The present study compares the human CD8+ T cell memory responses to H3N2 LAIVs with the Len/17 or the wild-type NP using an in vitro model. © 2018 Taylor & Francis.
Цитирование
Похожие публикации
Версии
- 1. Version of Record от 2021-04-27
Метаданные
Название журнала
- Human Vaccines and Immunotherapeutics
Том
- 14
Выпуск
- 4
Страницы
- 941-946
Ключевые слова
- epitope; influenza vaccine; nucleoprotein; influenza vaccine; live vaccine; nucleoprotein; virus antibody; animal cell; Article; CD8+ T lymphocyte; cellular immunity; controlled study; cross reaction; flow cytometry; human; human cell; immune response; immunization; immunogenicity; infection; influenza A (H1N1); influenza A (H3N2); lymphocyte proliferation; molecular typing; nonhuman; peripheral blood mononuclear cell; T lymphocyte activation; virus isolation; wild type; CD8+ T lymphocyte; immunology; influenza; Influenza A virus (H3N2); Russian Federation; tumor cell line; Antibodies, Viral; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Epitopes, T-Lymphocyte; Humans; Influenza A Virus, H3N2 Subtype; Influenza Vaccines; Influenza, Human; Nucleoproteins; Russia; Vaccines, Attenuated
Издатель
- Taylor and Francis Inc.
Тип документа
- journal article
Источник
- scopus
