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Статья
Phylogeography of the second plague pandemic revealed through analysis of historical Yersinia pestis genomes
2021
The second plague pandemic, caused by Yersinia pestis, devastated Europe and the nearby regions between the 14th and 18th centuries AD. Here we analyse human remains from ten European archaeological sites spanning this period and reconstruct 34 ancient Y. pestis genomes. Our data support an initial entry of the bacterium through eastern Europe, the absence of genetic diversity during the Black Death, and low within-outbreak diversity thereafter. Analysis of post-Black Death genomes shows the diversification of a Y. pestis lineage into multiple genetically distinct clades that may have given rise to more than one disease reservoir in, or close to, Europe. In addition, we show the loss of a genomic region that includes virulence-related genes in strains associated with late stages of the pandemic. The deletion was also identified in genomes connected with the first plague pandemic (541–750 AD), suggesting a comparable evolutionary trajectory of Y. pestis during both events. © 2019, The Author(s).
Цитирование
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Версии
- 1. Version of Record от 2021-04-27
Метаданные
Название журнала
- Nature Communications
Том
- 10
Выпуск
- 1
Страницы
- -
Ключевые слова
- archaeological evidence; bacterial disease; eighteenth century; epidemic; epidemiology; genetic variation; genome; phylogeography; Article; bacterial genome; bacterial strain; bacterial virulence; bacterium contamination; bacterium isolation; clinical assessment; DNA extraction; Eastern Europe; gene amplification; gene deletion; gene library; gene location; gene rearrangement; genetic analysis; genetic association; genetic variability; heterozygosity; high throughput sequencing; human; metagenomics; mgtB gene; mgtC gene; next generation sequencing; nonhuman; phylogenetic tree; phylogeny; phylogeography; plague; plasmid; quality control; real time polymerase chain reaction; screening test; single nucleotide polymorphism; Yersinia pestis; archeology; bacterial genome; chemistry; classification; fossil; genetics; microbiology; pandemic; pathogenicity; phylogeography; plague; procedures; time factor; virulence; Bacteria (microorganisms); Yersinia pestis; bacterial DNA; Archaeology; DNA, Bacterial; Europe, Eastern; Fossils; Genome, Bacterial; High-Throughput Nucleotide Sequencing; Humans; Pandemics; Phylogeny; Phylogeography; Plague; Polymorphism, Single Nucleotide; Time Factors; Virulence; Yersinia pestis
Издатель
- Nature Publishing Group
Тип документа
- journal article
Тип лицензии Creative Commons
- CC
Правовой статус документа
- Свободная лицензия
Источник
- scopus
