Статья

Phylogeny and classification of Yersinia pestis through the lens of strains from the Plague Foci of commonwealth of independent states

V. Kutyrev, G. Eroshenko, V. Motin, N. Nosov, J. Krasnov, L. Kukleva, K. Nikiforov, Z. Al'khova, E. Oglodin, N. Guseva,
2021

The established phylogeny of the etiological agent of plague, Yersinia pestis, is not perfect, as it does not take into account the strains from numerous natural foci of Commonwealth of Independent States (CIS). We have carried out PCR and SNP typing of 359 strains and whole genome sequencing of 51 strains from these plague foci and determined the phylogenetic diversity of the strains circulating here. They belong to 0.ANT3, 0.ANT5, 2.ANT3, 4.ANT branches of antique biovar, 2.MED0, 2.MED1 branches of medieval biovar and to 0.PE2, 0.PE4a. 0.PE4h, 0.PE4t branches. Based on the studies of 178 strains from 23 plague foci of CIS countries, it was determined that the population structure of 2.MED strains is subdivided into Caucasian-Caspian and Central Asian-Chinese branches. In Central-Caucasian high-mountain plague foci in the Russian Federation (RF) the most deeply diverged branch of medieval biovar, 2.MED0, has been found. With the data obtained, the current population structure of Y. pestis species has been refined. New subspecies classification is developed, comprising seven subspecies: pestis, caucasica (0.PE2), angolica (0.PE3), central asiatica (0.PE4), tibetica (0.PE7), ulegeica (0.PE5), and qinghaica (0.PE10). © 2018 Kutyrev, Eroshenko, Motin, Nosov, Krasnov, Kukleva, Nikiforov, Al'khova, Oglodin and Guseva.

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Версии

  • 1. Version of Record от 2021-04-27

Метаданные

Об авторах
  • V. Kutyrev
    Russian Research Anti-Plague Institute 'Microbe', Federal Service for Surveillance in the Sphere of Consumers Rights Protection and Human Welfare, Saratov, Russian Federation
  • G. Eroshenko
    Department of Pathology, University of Texas Medical Branch, Galveston, TX, United States
  • V. Motin
    Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, United States
  • N. Nosov
  • J. Krasnov
  • L. Kukleva
  • K. Nikiforov
  • Z. Al'khova
  • E. Oglodin
  • N. Guseva
Название журнала
  • Frontiers in Microbiology
Том
  • 9
Выпуск
  • MAY
Страницы
  • -
Ключевые слова
  • Article; Asia; biochemical analysis; bootstrapping; Caucasian; China; gene deletion; genetic analysis; genetic variability; intraspecific variation; microbial diversity; nonhuman; phylogenetic tree; phylogeny; plague; population structure; real time polymerase chain reaction; single nucleotide polymorphism; virulence; whole genome sequencing; Yersinia pestis
Издатель
  • Frontiers Media S.A.
Тип документа
  • journal article
Тип лицензии Creative Commons
  • CC
Правовой статус документа
  • Свободная лицензия
Источник
  • scopus