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Статья
Analysis of 3800-year-old Yersinia pestis genomes suggests Bronze Age origin for bubonic plague
2021
The origin of Yersinia pestis and the early stages of its evolution are fundamental subjects of investigation given its high virulence and mortality that resulted from past pandemics. Although the earliest evidence of Y. pestis infections in humans has been identified in Late Neolithic/Bronze Age Eurasia (LNBA 5000-3500y BP), these strains lack key genetic components required for flea adaptation, thus making their mode of transmission and disease presentation in humans unclear. Here, we reconstruct ancient Y. pestis genomes from individuals associated with the Late Bronze Age period (~3800 BP) in the Samara region of modern-day Russia. We show clear distinctions between our new strains and the LNBA lineage, and suggest that the full ability for flea-mediated transmission causing bubonic plague evolved more than 1000 years earlier than previously suggested. Finally, we propose that several Y. pestis lineages were established during the Bronze Age, some of which persist to the present day. © 2018 The Author(s).
Цитирование
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Версии
- 1. Version of Record от 2021-04-27
Метаданные
Название журнала
- Nature Communications
Том
- 9
Выпуск
- 1
Страницы
- -
Ключевые слова
- DNA fragment; virulence factor; ancient DNA; bacterial disease; bacterium; Bronze Age; disease transmission; evolution; flea; genome; infectious disease; mortality; Neolithic; virulence; Article; bacterial genome; bacterial transmission; bacterial virulence; Bronze Age; bubonic plague; DNA content; DNA screening; gene insertion sequence; genetic variability; heterozygosity; human; human tissue; immune evasion; metagenomics; mortality; next generation sequencing; nonhuman; nonsense mutation; operon; pandemic; pathogenicity; phylogeny; plague; Russian Federation; single nucleotide polymorphism; Yersinia pestis; Yersinia pseudotuberculosis; animal; bacterial genome; classification; flea; flea infestation; genetics; high throughput sequencing; microbiology; plague; tooth pulp; transmission; virulence; Yersinia pestis; Eurasia; Russian Federation; Russian Federation; Samara; Siphonaptera (fleas); Yersinia pestis; Animals; Dental Pulp; DNA, Ancient; Flea Infestations; Genome, Bacterial; High-Throughput Nucleotide Sequencing; Humans; Pandemics; Phylogeny; Plague; Polymorphism, Single Nucleotide; Russia; Siphonaptera; Virulence; Yersinia pestis
Издатель
- Nature Publishing Group
Тип документа
- journal article
Тип лицензии Creative Commons
- CC
Правовой статус документа
- Свободная лицензия
Источник
- scopus
