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New insight into secreted ribonuclease structure: Binase is a natural dimer

2021

///New insight into secreted ribonuclease structure: Binase is a natural dimer... Our study is the first report directly confirming the existence of binase dimers in solution and under natural conditions of enzyme biosynthesis and secretion by bacilli....

Uncertainties on the prognostic value of D-dimers in COVID-19 patients

J. Gris,

I. Quéré,

A. Pérez-Martin,

J. Lefrant,

A. Sotto

2021

///Uncertainties on the prognostic value of D-dimers in COVID-19 patients...

The association between D-dimers in COVID-19 patients and mortality remains beset of uncertainties

J. Gris,

P. Loubet,

C. Roger,

E. Cochery-Nouvellon,

J. Mauboussin,

L. Muller,

S. Bouvier,

D. Laureillard,

S. Barbar,

É. Mercier,

J. Lefrant,

A. Sotto

2021

///The association between D-dimers in COVID-19 patients and mortality remains beset of uncertainties...

The native monomer of bacillus pumilus ribonuclease does not exist extracellularly

O. Ilinskaya,

V. Ulyanova,

I. Lisevich,

E. Dudkina,

N. Zakharchenko,

A. Kusova,

D. Faizullin,

Y. Zuev

2021

Probably, the ratio of unstable binase dimers to highly stable swapping dimers which are simultaneously present in the medium is crucial.... The immutability of binase secondary structure upon transition from low to high protein concentration was registered, suggesting the binase dimerization immediately after translocation through the cell membrane and leading to detection of binase dimers...

Plasma hemostatic system in patients with the novel coronavirus disease 2019 (COVID-19)

M. Markelov,

O. Beznoshchenko,

T. Ivanets,

A. Pyregov,

R. Esayan,

T. Gavrilova,

L. Krechetova

2020

Laboratory investigations included APTT, Quick's prothrombin time, concentration of D-dimer, fibrinogen, ATIII, and platelet count. Results....

Snake venom phospholipases A2 possess a strong virucidal activity against SARS-CoV-2 in vitro and block the cell fusion mediated by spike glycoprotein interaction with the ACE2 receptor

A. Siniavin,

M. Nikiforova,

S. Grinkina,

V. Gushchin,

V. Starkov,

A. Osipov,

V. Tsetlin,

Y. Utkin

2021

Inactivation of the enzymatic activity of the catalytic subunit of dimeric PLA2 led to a significant decrease in antiviral activity. In addition, dimeric PLA2 inhibited cell-cell fusion mediated by SARS-CoV-2 spike glycoprotein....

Previous and First Detected Cardiovascular Diseases in Patients with New Coronavirus Pneumonia: Possible Mechanisms and Place in a Unified Prognostic Model

O. Blagova,

N. Varionchik,

V. Zaidenov,

P. Savina,

N. Sarkisova

2021

D-dimer level >0.5 μg/mL had a sensitivity of 79.2% and specificity of 60% in the prediction of cardio- vascular manifestations. The D-dimer over 1 μg/mL had specificity 90% (with decreasing sensitivity).... The most powerful prognostic model includes age, diabetes, oxygen therapy volume, maximum leukocyte level, C-reactive protein, and D-dimer (correlation coefficient 0.871, p < 0.001)....

Results of multicenter monitoring of hemostasis parameters in patients with covid-19

Bovt E.A.,

Brazhnik V.A.,

Bulanov A.Yu.,

Vasilyeva E.Yu.,

Vuimo T.А.,

Zateyshchikov E.N.,

Lipets D.A.,

Karamzin S.S.,

Lysenko M.A.,

Morozova D.A.,

Nechipurenko D.Yu.,