The article focuses on the impact of the COVID-19 pandemic on digitalization and public-private partnerships (PPPs) in medicine. The epidemic of this disease has intensively affected Russia, and the viral economic crisis has highlighted the need for structural reforms in many sectors of the economy, including medicine. The Russian Federation’s budget regularly lacks funds to solve much pressing health care and science problems. In this regard, PPP is of particular interest, promoting better management and higher medical services quality. Therefore, the purpose of the work is to consider the forms of interaction of advanced medical institutions with entrepreneurship, scientific organizations, regional administrations, civil society and the possibility of increasing the potential of such cooperation. A methodological basis of our research was a synergistic approach to scientific knowledge, institutional, cluster, general scientific analysis of sources, which made it possible to establish key aspects of the interaction of agents, and the SWOT analysis method made it possible to show, with some examples, the impact of PPP not only on the development of medical institutions but also on efficiency activities of the company.