The article is focused on a regional marketing and the study of the role of public-private partnership instruments in terms of the development of the regional infrastructure of Russia. Improving the investment climate is the main condition for the success of the socio-political and economic development of the state. The authors analyzed the current economic conditions and the consequences of sanctions against Russia, as well as the dependence of the economy on foreign direct investment. The paper considers the economic situation of the regions of the Russian Federation under the conditions of sanctions by Western countries in the formation of import substitution. Particular attention is paid to the mechanisms and methods of economic policy of the central and regional authorities of Russia in the use of tools and methods of regional marketing on the example of public-private partnerships (PPP), which help to attract investment to the regions and to the country as a whole, allowing finding additional financing, improving the efficiency of public investments.