In the context of coronavirus infection pandemic (COVID-19) in City Clinical Hospital 15 named after O.M. Filatov in the short-est possible time, unprecedented reorganization, construction, sanitary and epidemiological changes were carried out to organize the country’s largest infectious diseases clinic. Within a limited time frame, new working conditions were created for medical personnel and other hospital staff, to preserve their health, comfort and safety, to provide round-the-clock emergency care to patients with COVID-19. Such changes and the new working conditions created for medical personnel have allowed an increase in the number of corresponding beds to 1.796 and medical personnel performing diagnostics, treatment and care of patients with COV-ID-19 to 2402, curing over 13.000 patients from April 1 to July 1 Feb 2020.