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Статья
Phenoxazine nucleoside derivatives with a multiple activity against RNA and DNA viruses
2021
Emerging and re-emerging viruses periodically cause outbreaks and epidemics all over the world, eventually leading to global events such as the current pandemic of the novel SARS-CoV-2 coronavirus infection COVID-19. Therefore, an urgent need for novel antivirals is crystal clear. Here we present the synthesis and evaluation of an antiviral activity of phenoxazine-based nucleoside analogs divided into three groups: (1) 8-alkoxy-substituted, (2) acyclic, and (3) carbocyclic. The antiviral activity was assessed against a structurally and phylogenetically diverse panel of RNA and DNA viruses from 25 species. Four compounds (11a-c, 12c) inhibited 4 DNA/RNA viruses with EC ≤ 20 μM. Toxicity of the compounds for the cell lines used for virus cultivation was negligible in most cases. In addition, previously reported and newly synthesized phenoxazine derivatives were evaluated against SARS-CoV-2, and some of them showed promising inhibition of reproduction with EC values in low micromolar range, although accompanied by commensurate cytotoxicity. 50 50
Цитирование
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Версии
- 1. Version of Record от 2021-08-05
Метаданные
Название журнала
- European Journal of Medicinal Chemistry
Том
- 220
Финансирующая организация
- Russian Foundation for Basic Research
Номер гранта
- 1-Adamantylmethyl 5-amino-4
Тип документа
- journal article
Тип лицензии Creative Commons
- CC BY
Правовой статус документа
- Свободная лицензия
Источник
- scopus
