Disease-associated acrolein: A possible diagnostic and therapeutic substrate for in vivo synthetic chemistry

K. Muguruma; A. Pradipta; Y. Ode; K. Terashima; H. Michiba; M. Fujii; K. Tanaka

Статья

Disease-associated acrolein: A possible diagnostic and therapeutic substrate for in vivo synthetic chemistry

K. Muguruma, A. Pradipta, Y. Ode, K. Terashima, H. Michiba, M. Fujii, K. Tanaka,

2020

https://doi.org/10.1016/j.bmc.2020.115831

Acrolein, a highly reactive α,β-unsaturated aldehyde, is a compound to which humans are exposed in many different situations and often causes various human diseases. This paper summarizes the reports over the past twenty-five years regarding disease-associated acrolein detected in clinical patients and the role acrolein plays in various diseases. In several diseases, it was found that the increased acrolein acts as a pathogenetic factor. Thus, we propose the utility of over-produced acrolein as a substrate for a promising therapeutic or diagnostic method applicable to a wide range of diseases based on an in vivo synthetic chemistry strategy.

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1. Version of Record от 2020-12-15

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Об авторах

K. Muguruma
Tokyo Institute of Technology
A. Pradipta
Tokyo Institute of Technology
Y. Ode
Tokyo Institute of Technology
K. Terashima
Tokyo Institute of Technology
H. Michiba
Tokyo Institute of Technology
M. Fujii
Tokyo Institute of Technology
K. Tanaka
Tokyo Institute of Technology, Riken, Kazan Federal University

Название журнала

Bioorganic and Medicinal Chemistry

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Финансирующая организация

Japan Society for the Promotion of Science

Номер гранта

JP15H05843

Тип документа

journal article

Тип лицензии Creative Commons

CC BY

Правовой статус документа

Свободная лицензия

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scopus

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Статья

Disease-associated acrolein: A possible diagnostic and therapeutic substrate for in vivo synthetic chemistry

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