COVID-19.рф: ИНФОРМАЦИЯ ПРОТИВ ПАНДЕМИИ

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Статья

Multi-omics studies towards novel modulators of influenza a virus-host interaction

S. Söderholm, Y. Fu, L. Gaelings, S. Belanov, L. Yetukuri, M. Berlinkov, A. Cheltsov, S. Anders, T. Aittokallio, T. Nyman, S. Matikainen, D. Kainov,
2021
https://doi.org/10.3390/v8100269

Human influenza A viruses (IAVs) cause global pandemics and epidemics. These viruses evolve rapidly, making current treatment options ineffective. To identify novel modulators of IAV–host interactions, we re-analyzed our recent transcriptomics, metabolomics, proteomics, phosphoproteomics, and genomics/virtual ligand screening data. We identified 713 potential modulators targeting 199 cellular and two viral proteins. Anti-influenza activity for 48 of them has been reported previously, whereas the antiviral efficacy of the 665 remains unknown. Studying anti-influenza efficacy and immuno/neuro-modulating properties of these compounds and their combinations as well as potential viral and host resistance to them may lead to the discovery of novel modulators of IAV–host interactions, which might be more effective than the currently available anti-influenza therapeutics. © 2016 by the authors; licensee MDPI, Basel, Switzerland.

Цитирование

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Источник

Версии

  • 1. Version of Record от 2021-04-27

Метаданные

Об авторах
  • S. Söderholm
    Institute of Biotechnology, University of Helsinki, Helsinki, 00014, Finland
  • Y. Fu
    Finnish Institute of Occupational Health, Helsinki, 00250, Finland
  • L. Gaelings
    Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, 00014, Finland
  • S. Belanov
    Institute of Mathematics and Computer Science, Ural Federal University, Yekaterinburg, 620083, Russian Federation
  • L. Yetukuri
    Q-Mol L.L.C. in Silico Pharmaceuticals, San Diego, CA 92037, United States
  • M. Berlinkov
    Department of Mathematics and Statistics, University of Turku, Turku, 20014, Finland
  • A. Cheltsov
    Institute of Clinical Medicine, Oslo, 0450, Norway
  • S. Anders
    Department of Rheumatology, Helsinki University Hospital, University of Helsinki, Helsinki, 00015, Finland
  • T. Aittokallio
  • T. Nyman
  • S. Matikainen
  • D. Kainov
Название журнала
  • Viruses
Том
  • 8
Выпуск
  • 10
Страницы
  • -
Ключевые слова
  • antiviral activity; down regulation; genomics; immunomodulation; Influenza A virus; metabolomics; nonhuman; nuclear magnetic resonance spectroscopy; peripheral blood mononuclear cell; proteomics; Review; sequence alignment; transcriptomics; upregulation; virus cell interaction; X ray
Издатель
  • MDPI AG
Тип документа
  • Review
Тип лицензии Creative Commons
  • CC
Правовой статус документа
  • Свободная лицензия
Источник
  • scopus
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