Analyzed organization of preventive measures and patient care in Velikiy Novgorod in connection with the exceeding of the epidemic threshold for influenza and acute respiratory viral infections in 2016. The epidemic rise of influenza and other acute respiratory viral infections exceeded epidemiological and economic thresholds among the cumulative population on the territory of the Novgorod region started from the 3rd week 2016 (18.01.2016-24.01.2016) and continued for 4 weeks (until mid February). The peak of the epidemic was passed on the 4th calendar week of 2016, when the weekly prevalence rate was 135,7 per 10 thousand population (8447), the epidemic threshold was exceeded in 2 times. In terms of conversion to the infectious diseases hospital, a multidisciplinary clinic No. 2 "Central city clinical hospital" carried out specialized medical assistance 301 the patient with acute respiratory diseases and influenza, 67 of which were confirmed influenza caused by the H1N1 virus, of which 28 patients would, if hospitalized in serious and critical condition and needed to be held-Institute the intensive care manual.