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Статья
Epidemiology of hospital admissions with influenza during the 2013/2014 Northern hemisphere influenza season: Results from the Global Influenza Hospital Surveillance Network
2021
Background: The Global Influenza Hospital Surveillance Network was established in 2012 to obtain valid epidemiologic data on hospital admissions with influenza-like illness. Here we describe the epidemiology of admissions with influenza within the Northern Hemisphere sites during the 2013/2014 influenza season, identify risk factors for severe outcomes and complications, and assess the impact of different influenza viruses on clinically relevant outcomes in at-risk populations. Methods: Eligible consecutive admissions were screened for inclusion at 19 hospitals in Russia, Turkey, China, and Spain using a prospective, active surveillance approach. Patients that fulfilled a common case definition were enrolled and epidemiological data were collected. Risk factors for hospitalization with laboratory-confirmed influenza were identified by multivariable logistic regression. Findings: 5303 of 9507 consecutive admissions were included in the analysis. Of these, 1086 were influenza positive (534 A(H3N2), 362 A(H1N1), 130 B/Yamagata lineage, 3 B/Victoria lineage, 40 untyped A, and 18 untyped B). The risk of hospitalization with influenza (adjusted odds ratio [95% confidence interval]) was elevated for patients with cardiovascular disease (1.63 [1.33-2.02]), asthma (2.25 [1.67-3.03]), immunosuppression (2.25 [1.23-4.11]), renal disease (2.11 [1.48-3.01]), liver disease (1.94 [1.18-3.19], autoimmune disease (2.97 [1.58-5.59]), and pregnancy (3.84 [2.48-5.94]). Patients without comorbidities accounted for 60% of admissions with influenza. The need for intensive care or in-hospital death was not significantly different between patients with or without influenza. Influenza vaccination was associated with a lower risk of confirmed influenza (adjusted odds ratio = 0.61 [0.48- 0.77]). Conclusions: Influenza infection was detected among hospital admissions with and without known risk factors. Pregnancy and underlying comorbidity increased the risk of detecting influenza virus in patients hospitalized with influenza-like illness. Our results support influenza vaccination as a measure for reducing the risk of influenza-associated hospital admission. © 2016 Puig-Barberà et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Цитирование
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Версии
- 1. Version of Record от 2021-04-27
Метаданные
Название журнала
- PLoS ONE
Том
- 11
Выпуск
- 5
Страницы
- -
Ключевые слова
- influenza vaccine; adolescent; adult; aged; Article; asthma; autoimmune disease; cardiovascular disease; child; China; comorbidity; controlled study; disease surveillance; epidemiological data; female; flu like syndrome; hospital admission; hospital mortality; hospitalization; human; immune deficiency; infant; infection risk; influenza; influenza A (H1N1); influenza A (H3N2); influenza B; influenza vaccination; Influenza virus; intensive care; kidney disease; liver disease; major clinical study; male; middle aged; newborn; nonhuman; Northern Hemisphere; pregnancy; preschool child; prospective study; risk factor; risk reduction; Russian Federation; Spain; Turkey (republic); very elderly; clinical trial; cluster analysis; epidemiological monitoring; hospital admission; Influenza, Human; multicenter study; multivariate analysis; odds ratio; Orthomyxoviridae; outcome assessment; pregnancy complication; risk; Turkey; young adult; Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; China; Cluster Analysis; Comorbidity; Epidemiological Monitoring; Female; Humans; Infant; Infant, Newborn; Influenza, Human; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Orthomyxoviridae; Outcome Assessment (Health Care); Patient Admission; Pregnancy; Pregnancy Complications, Infectious; Prospective Studies; Risk; Risk Factors; Russia; Spain; Turkey; Young Adult
Издатель
- Public Library of Science
Тип документа
- journal article
Тип лицензии Creative Commons
- CC
Правовой статус документа
- Свободная лицензия
Источник
- scopus
