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Статья
Influenza epidemiology and influenza vaccine effectiveness during the 2015-2016 season: Results from the Global Influenza Hospital Surveillance Network
2021
Background: The Global Influenza Hospital Surveillance Network is an international platform whose primary objective is to study severe cases of influenza requiring hospitalization. Methods: During the 2015-2016 influenza season, 11 sites in the Global Influenza Hospital Surveillance Network in nine countries (Russian Federation, Czech Republic, Turkey, France, China, Spain, Mexico, India, and Brazil) participated in a prospective, active-surveillance, hospital-based epidemiological study. Influenza infection was confirmed by reverse transcription-polymerase chain reaction. Influenza vaccine effectiveness (IVE) against laboratory-confirmed influenza was estimated using a test-negative approach. Results: 9882 patients with laboratory results were included of which 2415 (24.4%) were positive for influenza, including 1415 (14.3%) for A(H1N1)pdm09, 235 (2.4%) for A(H3N2), 180 (1.8%) for A not subtyped, 45 (0.5%) for B/Yamagata-lineage, 532 (5.4%) for B/Victoria-lineage, and 33 (0.3%) for B not subtyped. Of included admissions, 39% were < 5 years of age and 67% had no underlying conditions. The odds of being admitted with influenza were higher among pregnant than non-pregnant women (odds ratio, 2.82 [95% confidence interval (CI), 1.90 to 4.19]). Adjusted IVE against influenza-related hospitalization was 16.3% (95% CI, 0.4 to 29.7). Among patients targeted for influenza vaccination, adjusted IVE against hospital admission with influenza was 16.2% (95% CI, - 3.6 to 32.2) overall, 23.0% (95% CI, - 3.3 to 42.6) against A(H1N1)pdm09, and - 25.6% (95% CI, - 86.3 to 15.4) against B/Victoria lineage. Conclusions: The 2015-2016 influenza season was dominated by A(H1N1)pdm09 and B/Victoria-lineage. Hospitalization with influenza often occurred in healthy and young individuals, and pregnant women were at increased risk of influenza-related hospitalization. Influenza vaccines provided low to moderate protection against hospitalization with influenza and no protection against the predominant circulating B lineage, highlighting the need for more effective and broader influenza vaccines. © 2019 The Author(s).
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Версии
- 1. Version of Record от 2021-04-27
Метаданные
Название журнала
- BMC Infectious Diseases
Том
- 19
Выпуск
- 1
Страницы
- -
Ключевые слова
- influenza vaccine; influenza vaccine; adolescent; adult; aged; Article; Brazil; child; China; controlled study; Czech Republic; disease severity; disease surveillance; drug efficacy; female; France; high risk population; hospital admission; hospitalization; human; India; infant; influenza; Influenza A virus (H1N1); Influenza A virus (H3N2); Influenza B virus; laboratory test; major clinical study; male; Mexico; newborn; pregnant woman; prospective study; protection; reverse transcription polymerase chain reaction; Russian Federation; Spain; trend study; Turkey (republic); virus strain; virus transmission; immunology; influenza; isolation and purification; middle aged; odds ratio; pregnancy; preschool child; season; statistics and numerical data; treatment outcome; young adult; Adolescent; Adult; Aged; Child; Child, Preschool; Female; Hospitalization; Humans; Influenza A Virus, H1N1 Subtype; Influenza A Virus, H3N2 Subtype; Influenza Vaccines; Influenza, Human; Male; Middle Aged; Odds Ratio; Pregnancy; Prospective Studies; Seasons; Treatment Outcome; Young Adult
Издатель
- BioMed Central Ltd.
Тип документа
- journal article
Тип лицензии Creative Commons
- CC
Правовой статус документа
- Свободная лицензия
Источник
- scopus
