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Статья
Immune pathogenesis of covid-19 intoxication: Storm or silence?
2021
Dysregulation of the immune system undoubtedly plays an important and, perhaps, determining role in the COVID-19 pathogenesis. While the main treatment of the COVID-19 intoxication is focused on neutralizing the excessive inflammatory response, it is worth considering an equally significant problem of the immunosuppressive conditions including immuno-paralysis, which lead to the secondary infection. Therefore, choosing a treatment strategy for the immune-mediated complications of coronavirus infection, one has to pass between Scylla and Charybdis, so that, in the fight against the “cytokine storm,” it is vital not to miss the point of the immune silence that turns into immuno-paralysis. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
Цитирование
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Версии
- 1. Version of Record от 2021-04-27
Метаданные
Название журнала
- Pharmaceuticals
Том
- 13
Выпуск
- 8
Страницы
- 1-17
Ключевые слова
- chemokine; corticosteroid; cytokine; Janus kinase inhibitor; tocilizumab; adult respiratory distress syndrome; cancer patient; continuous renal replacement therapy; coronavirus disease 2019; cytokine release; cytokine storm; dendritic cell; disease association; disease marker; disease severity; human; immune deficiency; immunopathology; lymphocytopenia; macrophage activation syndrome; mesenchymal stem cell; neutrophil count; plasma exchange; prognosis; regulatory T lymphocyte; Review; risk factor; T lymphocyte activation; virus infectivity
Издатель
- MDPI AG
Тип документа
- Review
Тип лицензии Creative Commons
- CC
Правовой статус документа
- Свободная лицензия
Источник
- scopus
