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Статья
Fundamental basis of covid-19 pathogenesis [Najznačajnije osnove patogeneze covid-19]
2021
At the end of 2019, a new coronavirus infection occurred in the People's Republic of China with an epicentre in the city of Wu-han. On February 11th, 2020, the World Health Organization as-signed the official name of the infection caused by the new coro-navirus – COVID-19. COVID-19 has affected people from all over the world given that the infection was noted in 200 countries resulting in annunciation of the pandemic situation. Human co-rona viruses cause mild to moderate respiratory infections. At the end of 2002, a new coronavirus appeared (SARS-CoV), the causal agent of atypical pneumonia, which caused acute respiratory distress syndrome (ARDS). The initial stage of COVID-19 infection is the penetration of SARS-CoV-2 into target cells that have angi-otensin converting enzyme type II receptors. The virus enters the body through the respiratory tract and interacts primarily with toll-like receptors (TLRs). The events in SARS-Cov-2 induced infection follow the next scenario: epithelial cells via TLRs recog-nize and identify SARS-Cov-2, and after that the information is transmitted to the transcriptional NF-κB, which causes expression of the corresponding genes. Activated in this way, the epithelial cells begin to synthesize various biologically active molecules. The results obtained on preclinical material indicate that ROS generation increases and the antioxidant protection decreases, which plays a major role in the pathogenesis of SARS-CoV, as well as in the progression and severity of this respiratory disease. © 2020, University of Kragujevac, Faculty of Science. All rights reserved.
Цитирование
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Версии
- 1. Version of Record от 2021-04-27
Метаданные
Название журнала
- Serbian Journal of Experimental and Clinical Research
Том
- 21
Выпуск
- 2
Страницы
- 93-111
Ключевые слова
- angiotensin converting enzyme 2; CXCL2 chemokine; granulocyte macrophage colony stimulating factor; immunoglobulin enhancer binding protein; interleukin 1 receptor associated kinase 1; interleukin 1 receptor associated kinase 4; interleukin 18; interleukin 1beta; interleukin 6; interleukin 8; macrophage inflammatory protein 1alpha; macrophage inflammatory protein 1beta; myeloid differentiation factor 88; protein p53; reactive oxygen metabolite; reduced nicotinamide adenine dinucleotide phosphate oxidase; toll like receptor 1; toll like receptor 10; toll like receptor 2; toll like receptor 3; toll like receptor 4; toll like receptor 5; toll like receptor 6; tumor necrosis factor receptor associated factor 3; adaptive immunity; adult respiratory distress syndrome; antioxidant activity; apoptosis; Article; atelectasis; atherosclerosis; BCG vaccination; cell proliferation; cell viability; coronavirus disease 2019; DNA damage; endothelial dysfunction; epithelium cell; hospitalization; human; inflammation; innate immunity; legionnaire disease; leprosy; lung edema; macrophage; mortality; multiple organ failure; oxidative stress; pandemic; pathogenesis; phylogeny; Severe acute respiratory syndrome coronavirus 2; syphilis; virus entry; virus transmission
Издатель
- University of Kragujevac, Faculty of Science
Тип документа
- journal article
Тип лицензии Creative Commons
- CC
Правовой статус документа
- Свободная лицензия
Источник
- scopus
