The article is devoted to assessing the construction of regulation and ensuring food security at the international and national levels. The object of the study was the methods of regulation and management of socio- economic effects of AIC regional-sectoral structures, influencing the stability of the food security provision system. The hypothesis of the study is the assertion that the quality of international and national legal regulation positively correlates with the quality of food security provision. The article analyzes the complex of international social and economic institutions in a hierarchical way through the use of institutional methodology. The author analyzes the data illustrating the practice and dynamics of normative-legal provision of the system ensuring food security in the conditions of difficult epidemiological situation. Based on the results of the study, the main trends and directions of development in the field of regulation and ensuring food security in the face of threats and large challenges is evaluated. © The Authors, published by EDP Sciences, 2020.