Статья

Lung epithelial stem cells express SARS-CoV-2 entry factors: implications for COVID-19

A. Valyaeva, A. Zharikova, A. Kasianov, Y. Vassetzky, E. Sheval,
2020

SARS-CoV-2 can infiltrate the lower respiratory tract, resulting in severe respiratory failure and a high death rate. Normally, the airway and alveolar epithelium can be rapidly reconstituted by multipotent stem cells after episodes of infection. Here, we analyzed published RNA-seq datasets and demonstrated that cells of four different lung epithelial stem cell types express SARS-CoV-2 entry factors, including Ace2. Thus, stem cells can be potentially infected by SARS-CoV-2, which may lead to defects in regeneration capacity partially accounting for the severity of SARS-CoV-2 infection and its consequences.

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  • 1. Version of Record от 2020-05-23

Метаданные

Об авторах
  • A. Valyaeva
    Moscow State University
  • A. Zharikova
    Russian Academy of Sciences; Moscow State University
  • A. Kasianov
    Russian Academy of Sciences
  • Y. Vassetzky
    Institut Gustave Roussy
  • E. Sheval
    Moscow State University
Предметная рубрика
  • COVID-19
Тип документа
  • other
Тип лицензии Creative Commons
  • CC BY-NC
Правовой статус документа
  • Свободная лицензия
Источник
  • lens