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Статья
Expression of SARS-CoV-2 entry factors in lung epithelial stem cells and its potential implications for COVID-19
2021
SARS-CoV-2 can infiltrate the lower respiratory tract, resulting in severe respiratory failure and a high death rate. Normally, the airway and alveolar epithelium can be rapidly reconstituted by multipotent stem cells after episodes of infection. Here, we analyzed published RNA-seq datasets and demonstrated that cells of four different lung epithelial stem cell types express SARS-CoV-2 entry factors, including Ace2. Thus, stem cells can be potentially infected by SARS-CoV-2, which may lead to defects in regeneration capacity partially accounting for the severity of SARS-CoV-2 infection and its consequences. © 2020, The Author(s).
Цитирование
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Версии
- 1. Version of Record от 2021-04-27
Метаданные
Название журнала
- Scientific Reports
Том
- 10
Выпуск
- 1
Страницы
- -
Ключевые слова
- angiotensin converting enzyme 2; dipeptidyl carboxypeptidase; serine proteinase; TMPRSS2 protein, human; viral protein; Betacoronavirus; cell differentiation; cell line; Coronavirus infection; cytology; genetics; human; isolation and purification; lung; metabolism; pandemic; pathology; physiology; stem cell; virology; virus entry; virus pneumonia; Betacoronavirus; Cell Differentiation; Cell Line; Coronavirus Infections; Humans; Lung; Pandemics; Peptidyl-Dipeptidase A; Pneumonia, Viral; Serine Endopeptidases; Stem Cells; Viral Proteins; Virus Internalization
Издатель
- Nature Research
Тип документа
- journal article
Тип лицензии Creative Commons
- CC
Правовой статус документа
- Свободная лицензия
Источник
- scopus
