The polarization and shrinkage of inhabited and economically active areas as a result of their extremely uneven development has become one of the key problems for not only the whole of Russia and its macro-regions, but also for individual regions and groups of them. A study of one group, located in the country's historical core around Moscow, reveals sharp and growing contrasts of the center-periphery type, which are, generally speaking, particularly common in Russia. Factors behind this have been the specifics of crisis-prone urbanization, centripetal migration, and depopulation of inner peripheries, particularly rural ones, under the post-Soviet spatial restructuring of the economy and settlement pattern. These processes are painful for both poles, the central as well as the peripheral, but the latter experiences more acute related problems and feels them more sharply. Their public, expert and official perceptions are different. The paper identifies four possible basic approaches to these problems, along with possible policies and solutions, such as (1) non-interference in the spirit of laissez-faire with the hopes of a natural change (reversal) of the shrinking trend; (2) acceleration of the trend in order to save budget funds by enlarging settlements and social facilities; (3) containment and mitigation of the trend’s negative social consequences by affordable measures; and (4) the search and multi-faceted support for new, reverse waves of development (a kind of reconquest) of the empty periphery, among which the country (dachas) wave stands out as one of the most realistic, massive and, moreover, least costly for the state. Each option has its pluses and minuses, strengths and weaknesses, a quick review of which is contained in the article. But the choice of this or that path remains, as usual, up to politicians and managers.