Статья

Study of the effectiveness of methylprednisolone at different stages of inpatient care for patients with pneumonia caused by a new COVID-19 coronavirus infection

E. Arinina, R. Tairova, A. Berdalin, S. Gujev, N. Glotova, Y. Rubleva, M. Bulatova, B. Polyaev, D. Terechov, Belousov VV, N. Shamalov,
2020

Glucocorticoid therapy for a cytokine storm is one of the mainstays of managing the novel coronavirus disease COVID-19. The aim of this study was to evaluate the efficacy of methylprednisolone at different stages of medical care: in an intensive care unit (ICU) vs. a medical ward setting. Methylprednisolone therapy was delivered to 54 patients, amounting to 9% of the total patients hospitalized to the Federal Center of Brain Research and Neurotechnology of FMBA, Russia. Twenty-eight patients received methylprednisolone in the ICU setting; 26 patients, in a medical ward setting. The control group comprised 14 patients. Methylprednisolone was administered continuously, intravenously at 250 mg per day over the course of 3 days; the total dose was 750 mg. The analysis revealed a significant reduction in mortality in the group receiving methylprednisolone in a medical ward setting (7.7%) in comparison with the group receiving the drug in ICU (67.9%) and the control group (42.9%, р

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Версии

  • 1. Version of Record от 2020-08-17

Метаданные

Об авторах
  • E. Arinina
    Federal Center for Brain and Neurotechnology of FMBA of Russia, Moscow, Russia
  • R. Tairova
    Federal Center for Brain and Neurotechnology of FMBA of Russia, Moscow, Russia
  • A. Berdalin
    Federal Center for Brain and Neurotechnology of FMBA of Russia, Moscow, Russia
  • S. Gujev
    Federal Center for Brain and Neurotechnology of FMBA of Russia, Moscow, Russia
  • N. Glotova
    Federal Center for Brain and Neurotechnology of FMBA of Russia, Moscow, Russia
  • Y. Rubleva
    Federal Center for Brain and Neurotechnology of FMBA of Russia, Moscow, Russia
  • M. Bulatova
    Federal Center for Brain and Neurotechnology of FMBA of Russia, Moscow, Russia
  • B. Polyaev
    Federal Center for Brain and Neurotechnology of FMBA of Russia, Moscow, Russia
  • D. Terechov
    A.I. Burnazyan Federal Medical Biophysical Center of FMBA of Russia, Moscow, Russia
  • Belousov VV
    Federal Center for Brain and Neurotechnology of FMBA of Russia, Moscow, Russia
  • N. Shamalov
    Federal Center for Brain and Neurotechnology of FMBA of Russia, Moscow, Russia
Название журнала
  • Bulletin officiel
Выпуск
  • (3)2020
Издатель
  • Federal Medical Biological Agency
Тип документа
  • journal article
Тип лицензии Creative Commons
  • CC BY
Правовой статус документа
  • Свободная лицензия
Источник
  • dimensions