The impact of the interaction of governance and information and communication technologies (ICT) adoption on food security in West Africa is investigated in this study. The study engaged the system generalised method of moments (GMM) approach on a panel data of 15 West African countries. The data used for the study are obtained from the world development indicators (WDI) and world governance indicators (WGI), for the period 2005 to 2018. The findings show that good governance (government effectiveness and efficient anti-corruption control) can boost food security by between 12% and 20%. Furthermore, the findings show that a 1% rise in ICT adoption may boost food security by 12% to 15%. In explaining the level of food security, the relationship between governance and ICT adoption is positive and significant. This implies that ICT and governance (government effectiveness) interaction may have about 15% positive influence on food security, while ICT and control of corruption interaction may positively influence the level of food security by 8%. The study concludes by recommending that to enhance food security in West Africa, effectiveness in governance and ICT adoption are crucial.