Low homology between 2019-nCoV Orf8 protein and its SARS-CoV counterparts questions their identical function

V. Iatsenko; K. Boyarshin; O. Bespalova; V. Klyueva; Y. Kurkina; I. Batlutskaya

Статья

Low homology between 2019-nCoV Orf8 protein and its SARS-CoV counterparts questions their identical function

V. Iatsenko, K. Boyarshin, O. Bespalova, V. Klyueva, Y. Kurkina, I. Batlutskaya,

2021

https://doi.org/10.1051/bioconf/20213005008

SARS-CoV accessory protein Orf8b is involved in suppressing interferon-mediated immune response of the infected cell and this might lead to supposition that the corresponding protein 2019-nCoV Orf8 shares the same role. But the tertiary structures of these proteins are still unknown, and the primary structures demonstrate very low homology and different calculating parameters. This time they both are affected by stabilizing selection and in natural viral populations do not tend to be deleted. The question whether in this case very different proteins could share the same function rises from the present data.

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1. Version of Record от 2021-04-22

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Об авторах

V. Iatsenko
Belgorod State National Research University, Belgorog, Russia
K. Boyarshin
Belgorod State National Research University, Belgorog, Russia
O. Bespalova
Belgorod State National Research University, Belgorog, Russia
V. Klyueva
Belgorod State National Research University, Belgorog, Russia
Y. Kurkina
Belgorod State National Research University, Belgorog, Russia
I. Batlutskaya
Belgorod State National Research University, Belgorog, Russia

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BIO Web of Conferences

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05008

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EDP Sciences

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journal article

Тип лицензии Creative Commons

CC BY

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Свободная лицензия

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Статья

Low homology between 2019-nCoV Orf8 protein and its SARS-CoV counterparts questions their identical function

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