The infrastructure spatial planning is at the heart of modern sustainable development issues. The methods for selecting an infrastructure project for construction are an important conceptual basis for sustainable development, which provide effective assistance to the development of territories. The study is aimed at finding and analyzing existing approaches and tools for assessing territorial development in the reproductive structure of the economy, as well as developing a methodological and procedural assessment of large infrastructure projects to solve socio-economic problems. The methods of analysis of causes and effects, as well as methods of investment planning are used. At the same time, according to the authors, the main conceptual and methodological prerequisite that distinguishes the proposed approach should take into account the effects of intersectoral interaction. It is necessary to assess the contribution to the sustainable development of territories “with a project” and “without a project”.