The study provides an assessment of the state and prospects of sustainable agriculture in a large industrial region, which is the Sverdlovsk region, as the basis for its sustainable development in the new economic realities generated by the global pandemic of 2020 associated with the threats of COVID-19. The hypothesis of the study is the assumption that the sustainable development of agriculture in the region in the new conditions is provided by the accumulated economic potential in the conditions of the coronacrisis contradictions trigger. The purpose of the study is a comprehensive assessment of the real potential and level of food supply in the Sverdlovsk region, which is provided by agricultural producers, based on the analysis of their numerical composition, geographical location and the allocation of the structural orientation of their activities, the dynamics of its development in the context of new strategic challenges. An economic and statistical study of the agricultural sector of the economy of a large industrial region, the Sverdlovsk region, was conducted. To ensure representativeness, 143 agricultural producers were studied and the existing enterprises of the Sverdlovsk region were grouped as of 01.09.2020.