Mortality and Transfusion Requirements in COVID-19 Hospitalized Italian Patients According to Severity of the Disease

E. Grandone; R. Pesavento; G. Tiscia; A. De Laurenzo; D. Ceccato; M. Sartori; L. Mirabella; G. Cinnella; M. Mastroianno; L. Dalfino; D. Colaizzo; R. Vettor; A. Ostuni; M. Margaglione

Статья

Mortality and Transfusion Requirements in COVID-19 Hospitalized Italian Patients According to Severity of the Disease

E. Grandone, R. Pesavento, G. Tiscia, A. De Laurenzo, D. Ceccato, M. Sartori, L. Mirabella, G. Cinnella, M. Mastroianno, L. Dalfino, D. Colaizzo, R. Vettor, A. Ostuni, M. Margaglione,

2021

https://doi.org/10.3390/jcm10020242

There is paucity of data on the transfusion need and its impact on the overall mortality in patients with COVID-19. We explored mortality in hospitalized patients with COVID-19 who required transfusions. Information on clinical variables and in-hospital mortality were obtained from medical records of 422 patients admitted to medical wards or the Intensive Care Unit (ICU). In-hospital mortality occurred in 147 (34.8%) patients, 94 (63.9%) of whom were admitted to the ICU. The median fatalities age was 77 years (IQR 14). Overall, 100 patients (60 males) received transfusion during hospitalization. The overall mortality was significantly and independently associated with age, ICU admission, Chronic Kidney Disease (CKD), and the number of transfused Red Blood Cell (RBC) units. Specifically, CKD was associated with mortality in patients admitted to medical wards, whereas the number of transfused RBC units predicted mortality in those admitted to the ICU. Transfusion strongly interacted with the admission to ICU (OR: 9.9; 95% CI: 2.5-40.0). In patients with COVID-19, age is one of the strongest risk factors in predicting mortality independently of the disease's severity. CKD confers a higher risk of mortality in patients admitted to medical wards. In those admitted to the ICU, the more RBC units are transfused, the more mortality increases.

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E. Grandone
Thrombosis and Haemostasis Unit, Fondazione I.R.C.C.S. “Casa Sollievo della Sofferenza”, 71013 San Giovanni Rotondo, Italy;, g.tiscia@operapadrepio.it, (G.T.);, antonio.delaurenzo@operapadrepio.it, (A.D.L.);, d.colaizzo@operapadrepio.it, (D.C.), Ob/Gyn Department of the First I.M. Sechenov Moscow State Medical University, 119435 Moscow, Russia
R. Pesavento
Department of Internal Medicine, University of Padua, 35122 Padua, Italy;, r.pesavento@unipd.it, (R.P.);, ceccatodavide@gmail.com, (D.C.);, mtsartori@unipd.it, (M.T.S.);, roberto.vettor@unipd.it, (R.V.)
G. Tiscia
Thrombosis and Haemostasis Unit, Fondazione I.R.C.C.S. “Casa Sollievo della Sofferenza”, 71013 San Giovanni Rotondo, Italy;, g.tiscia@operapadrepio.it, (G.T.);, antonio.delaurenzo@operapadrepio.it, (A.D.L.);, d.colaizzo@operapadrepio.it, (D.C.)
A. De Laurenzo
Thrombosis and Haemostasis Unit, Fondazione I.R.C.C.S. “Casa Sollievo della Sofferenza”, 71013 San Giovanni Rotondo, Italy;, g.tiscia@operapadrepio.it, (G.T.);, antonio.delaurenzo@operapadrepio.it, (A.D.L.);, d.colaizzo@operapadrepio.it, (D.C.)
D. Ceccato
Department of Internal Medicine, University of Padua, 35122 Padua, Italy;, r.pesavento@unipd.it, (R.P.);, ceccatodavide@gmail.com, (D.C.);, mtsartori@unipd.it, (M.T.S.);, roberto.vettor@unipd.it, (R.V.)
M. Sartori
Department of Internal Medicine, University of Padua, 35122 Padua, Italy;, r.pesavento@unipd.it, (R.P.);, ceccatodavide@gmail.com, (D.C.);, mtsartori@unipd.it, (M.T.S.);, roberto.vettor@unipd.it, (R.V.)
L. Mirabella
Department of Anesthesia and Intensive care, University of Foggia, 71122 Foggia, Italy;, l.mirabella@unifg.it, (L.M.);, g.cinnella@unifg.it, (G.C.)
G. Cinnella
Department of Anesthesia and Intensive care, University of Foggia, 71122 Foggia, Italy;, l.mirabella@unifg.it, (L.M.);, g.cinnella@unifg.it, (G.C.)
M. Mastroianno
Scientific Direction, Fondazione I.R.C.C.S. “Casa Sollievo della Sofferenza”, 71013 San Giovanni Rotondo, Italy;, m.mastroianno@operapadrepio.it
L. Dalfino
Anesthesia and Intensive care Unit, University of Bari, 70121 Bari, Italy;, lidia.dalfino@yahoo.com
D. Colaizzo
Thrombosis and Haemostasis Unit, Fondazione I.R.C.C.S. “Casa Sollievo della Sofferenza”, 71013 San Giovanni Rotondo, Italy;, g.tiscia@operapadrepio.it, (G.T.);, antonio.delaurenzo@operapadrepio.it, (A.D.L.);, d.colaizzo@operapadrepio.it, (D.C.)
R. Vettor
Department of Internal Medicine, University of Padua, 35122 Padua, Italy;, r.pesavento@unipd.it, (R.P.);, ceccatodavide@gmail.com, (D.C.);, mtsartori@unipd.it, (M.T.S.);, roberto.vettor@unipd.it, (R.V.)
A. Ostuni
Immunohematology and Transfusion Medicine Service, Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari, University of Bari “Aldo Moro”, Struttura Regionale Coordinamento, 70124 Bari, Italy;, angelo.ostuni@policlinico.ba.it
M. Margaglione
Medical Genetics, University of Foggia, 71122 Foggia, Italy;, m.margaglione@unifg.it

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Mortality and Transfusion Requirements in COVID-19 Hospitalized Italian Patients According to Severity of the Disease

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