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Статья
On the prospects of using vitamins and minerals in the prevention of early pregnancy losses
2021
The pathophysiology of sporadic miscarriage in early pregnancy is complex and includes chromosomal defects, thrombotic disorders, and elevated chronic systemic inflammation levels in particular. The associations between hypovitaminoses, dysmicroelementoses, and the pathophysiology of thrombophilia and chronic inflammation point to the promise for replenishing vitamin and mineral deficiencies to lower the risk of early pregnancy losses (EPL). The paper presents the results of fundamental and clinical studies of the relationship between reproductive losses and the provision of patients with vitamins B , D, E, B , folate, iron, selenium, zinc, magnesium, and omega-3 polyunsaturated fatty acids (PUFAs). In order to prevent EPL, vitamin E mono-preparations are not recommended for administration especially in large doses during pregnancy. In women with unexplained EPL, vitamin D deficiency (at serum 25(OH)D concentration less than 30 ng/ml) should be compensated, since the low vitamin D status reduces the effects of progesterone, increases the risk of thrombogenesis and inflammation, and is associated with a decrease in regulatory T-lymphocytes. In order to prevent spontaneous abortion, it is optimal to take multicomponent vitamin and mineral complexes. Vitamin D deficiency is most effectively compensated with a combination of vitamins A, C, B , B , B , B , B , and omega-3 PUFAs. Conclusion. Vitamin and micronutrient deficiencies in women with EPL are an urgent problem in obstetrics. Compensation of micronutrient deficiencies is a pathophysiological approach to reducing the risk of EPL. 9 12 3 3 1 2 5 6 9
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Версии
- 1. Version of Record от 2021-01-01
Метаданные
Название журнала
- Akusherstvo i Ginekologiya (Russian Federation)
Том
- 2021
Выпуск
- 4
Страницы
- 12-22
Номер гранта
- undefined
Тип документа
- journal article
Тип лицензии Creative Commons
- CC BY
Правовой статус документа
- Свободная лицензия
Источник
- scopus
