Clinical significance of measuring ADAMTS-13, its inhibitor and von Willebrand factor in obstetric and gynecological practice

K. Grigoreva; V. Bitsadze; J. Khizroeva; M. Tretyakova; D. Ponomarev; K. Tsvetnova; D. Doronicheva; A. Mamaeva; K. Mekhedova; G. Rizzo; J. Gris; I. Elalamy; A. Makatsariya

Статья

Clinical significance of measuring ADAMTS-13, its inhibitor and von Willebrand factor in obstetric and gynecological practice

K. Grigoreva, V. Bitsadze, J. Khizroeva, M. Tretyakova, D. Ponomarev, K. Tsvetnova, D. Doronicheva, A. Mamaeva, K. Mekhedova, G. Rizzo, J. Gris, I. Elalamy, A. Makatsariya,

2021

https://doi.org/10.17749/2313-7347/OB.GYN.REP.2021.203

ADAMTS-13 is a crucial metalloproteinase involved in liberating fragments of von Willebrand factor (vWF) into the plasma as well as regulating its activity by cleaving "ultra-large" multimers into smaller and less active counterparts. Many pathological conditions, including those emerged during pregnancy are characterized by increased level of vWF and decreased ADAMTS-13 activity. In this regard, it is necessary to monitor the levels of vWF and ADAMTS-13 activity to prevent thrombotic thrombocytopenic purpura (Moschcowitz disease) as one of the most severe forms of thrombotic microangiopathy.

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1. Version of Record от 2021-01-01

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Об авторах

K. Grigoreva
Sechenov First Moscow State Medical University
V. Bitsadze
Sechenov First Moscow State Medical University
J. Khizroeva
Sechenov First Moscow State Medical University
M. Tretyakova
«Medical Center» LLC
D. Ponomarev
Moscow Healthcare Department
K. Tsvetnova
Moscow Healthcare Department
D. Doronicheva
Sechenov First Moscow State Medical University
A. Mamaeva
Sechenov First Moscow State Medical University
K. Mekhedova
Sechenov First Moscow State Medical University
G. Rizzo
Sechenov First Moscow State Medical University, Università degli Studi di Roma Tor Vergata
J. Gris
Sechenov First Moscow State Medical University, Université de Montpellier
I. Elalamy
Sechenov First Moscow State Medical University, Sorbonne Universite, Hôpital Tenon
A. Makatsariya
Sechenov First Moscow State Medical University

Название журнала

Obstetrics, Gynecology and Reproduction

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Выпуск

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93-106

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journal article

Тип лицензии Creative Commons

CC BY

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Свободная лицензия

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scopus

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Статья

Clinical significance of measuring ADAMTS-13, its inhibitor and von Willebrand factor in obstetric and gynecological practice

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