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Comparative Study of Wound-Healing Activity of Dihydroquercetin Pseudopolymorphic Modifications

R. Terekhov, I. Selivanova, M. Anurova, A. Zhevlakova, I. Nikitin, Z. Cong, S. Ma, F. Yang, Z. Dong, Y. Liao,
2021
https://doi.org/10.1007/s10517-021-05083-w

Wound-healing activity of the crystalline form of dihydroquercetin and its microtubular pseudopolymorphic modification obtained by crystal engineering was compared using the rat model of IIIA degree burn. The rate of wound healing in the group treated with microtubular pseudopolymorphic modification of dihydroquercetin was 4.8±0.1%, which was higher by 11.6% than in the group treated with crystalline form (4.3±0.1%). Bioavailability analysis on MDCK cell culture showed that the apparent permeability coefficient of microtubular pseudopolymorphic modification was higher than that of crystalline form by 31.1% (19.4±0.2×10 and 14.8±0.3×10 cm/sec, respectively). It was proven that the use of crystal engineering improved the biopharmaceutical parameters of dihydroquercetin and increased its pharmacological efficiency. –4 –4

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Документы

Источник

Версии

  • 1. Version of Record от 2021-02-01

Метаданные

Об авторах
  • R. Terekhov
    Sechenov First Moscow State Medical University
  • I. Selivanova
    Sechenov First Moscow State Medical University
  • M. Anurova
    Sechenov First Moscow State Medical University
  • A. Zhevlakova
    Sechenov First Moscow State Medical University
  • I. Nikitin
    Sechenov First Moscow State Medical University
  • Z. Cong
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College
  • S. Ma
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College
  • F. Yang
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College
  • Z. Dong
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College
  • Y. Liao
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College
Название журнала
  • Bulletin of Experimental Biology and Medicine
Том
  • 170
Выпуск
  • 4
Страницы
  • 444-447
Номер гранта
  • undefined
Тип документа
  • journal article
Тип лицензии Creative Commons
  • CC BY
Правовой статус документа
  • Свободная лицензия
Источник
  • scopus
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