Статья

Thymidine and stavudine molecules in reactions with low-energy electrons

M. Muftakhov, P. Shchukin, R. Khatymov,
2021

The negative ion formation and fragmentation processes in thymidine and stavudine were studied by means of resonant electron capture mass spectrometry in the electron energy range 0–14 eV. Stavudine is a nucleoside analog of thymidine, that differs from the latter by the presence of double bond in the deoxyribose moiety. In the energy range below 5 eV transient negative ions have been found to arise via shape resonances resulting in electron attachment into the empty π*-orbitals. The main fragmentation channels for molecular ions are the H-atom loss and N-glycosidic bond cleavage between sugar and a nucleobase moieties. The dissociative electron attachment cross sections for the fragment negative ions were measured. The structures for some observed anions and neutral counterparts were suggested basing on the thermochemical approach for dissociative reactions energy balance under the support of quantum chemical calculations. The processes of ion formation in thymidine were found to be similar to those revealed previously for deoxyuridine nucleoside. In contrast, very strong dissociative channel was found for stavudine yielding [M–R] ions (where R is a sugar moiety) in the energy range

Цитирование

Похожие публикации

Документы

Источник

Версии

  • 1. Version of Record от 2021-07-01

Метаданные

Об авторах
  • M. Muftakhov
    Russian Academy of Sciences
  • P. Shchukin
    Russian Academy of Sciences
  • R. Khatymov
    Russian Academy of Sciences
Название журнала
  • Radiation Physics and Chemistry
Том
  • 184
Номер гранта
  • undefined
Тип документа
  • journal article
Тип лицензии Creative Commons
  • CC BY
Правовой статус документа
  • Свободная лицензия
Источник
  • scopus