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Статья
Preexisting autoantibodies to type I IFNs underlie critical COVID-19 pneumonia in patients with APS-1
P. Bastard,
E. Orlova,
L. Sozaeva,
R. Lévy,
A. James,
M. Schmitt,
S. Ochoa,
M. Kareva,
Y. Rodina,
A. Gervais,
T. Le Voyer,
J. Rosain,
Q. Philippot,
A. Neehus,
E. Shaw,
M. Migaud,
L. Bizien,
O. Ekwall,
S. Berg,
G. Beccuti,
L. Ghizzoni,
G. Thiriez,
A. Pavot,
C. Goujard,
M. Frémond,
E. Carter,
A. Rothenbuhler,
A. Linglart,
B. Mignot,
A. Comte,
N. Cheikh,
O. Hermine,
L. Breivik,
E. Husebye,
S. Humbert,
P. Rohrlich,
A. Coaquette,
F. Vuoto,
K. Faure,
N. Mahlaoui,
P. Kotnik,
T. Battelino,
K. Trebušak Podkrajšek,
K. Kisand,
E. Ferré,
T. DiMaggio,
L. Rosen,
P. Burbelo,
M. McIntyre,
N. Kann,
A. Shcherbina,
M. Pavlova,
A. Kolodkina,
S. Holland,
S. Zhang,
Y. Crow,
L. Notarangelo,
H. Su,
L. Abel,
M. Anderson,
E. Jouanguy,
B. Neven,
A. Puel,
J. Casanova,
M. Lionakis,
2021
Patients with biallelic loss-of-function variants of AIRE suffer from autoimmune polyendocrine syndrome type-1 (APS-1) and produce a broad range of autoantibodies (auto-Abs), including circulating auto-Abs neutralizing most type I interferons (IFNs). These auto-Abs were recently reported to account for at least 10% of cases of life-threatening COVID-19 pneumonia in the general population. We report 22 APS-1 patients from 21 kindreds in seven countries, aged between 8 and 48 yr and infected with SARS-CoV-2 since February 2020. The 21 patients tested had auto-Abs neutralizing IFN-α subtypes and/or IFN-ω; one had anti-IFN-β and another anti-IFN-ε, but none had anti-IFN-κ. Strikingly, 19 patients (86%) were hospitalized for COVID-19 pneumonia, including 15 (68%) admitted to an intensive care unit, 11 (50%) who required mechanical ventilation, and four (18%) who died. Ambulatory disease in three patients (14%) was possibly accounted for by prior or early specific interventions. Preexisting auto-Abs neutralizing type I IFNs in APS-1 patients confer a very high risk of life-threatening COVID-19 pneumonia at any age.
Цитирование
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Версии
- 1. Version of Record от 2021-07-05
Метаданные
Об авторах
-
P. Bastard
Hôpital Necker Enfants Malades, Université de Paris, Rockefeller University -
E. Orlova
Endocrinology Research Centre -
L. Sozaeva
Endocrinology Research Centre -
R. Lévy
Hôpital Necker Enfants Malades, Université de Paris, Hôpital Necker Enfants Malades -
A. James
National Institute of Allergy and Infectious Diseases (NIAID) -
M. Schmitt
National Institute of Allergy and Infectious Diseases (NIAID) -
S. Ochoa
National Institute of Allergy and Infectious Diseases (NIAID) -
M. Kareva
Endocrinology Research Centre -
Y. Rodina
Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology -
A. Gervais
Hôpital Necker Enfants Malades, Université de Paris -
T. Le Voyer
Hôpital Necker Enfants Malades, Université de Paris -
J. Rosain
Hôpital Necker Enfants Malades, Université de Paris -
Q. Philippot
Hôpital Necker Enfants Malades, Université de Paris -
A. Neehus
Hôpital Necker Enfants Malades, Université de Paris -
E. Shaw
National Institute of Allergy and Infectious Diseases (NIAID) -
M. Migaud
Hôpital Necker Enfants Malades -
L. Bizien
Hôpital Necker Enfants Malades -
O. Ekwall
Göteborg University, Sahlgrenska Academy, Göteborg University, Sahlgrenska Academy -
S. Berg
Göteborg University, Sahlgrenska Academy -
G. Beccuti
Università degli Studi di Torino -
L. Ghizzoni
Università degli Studi di Torino -
G. Thiriez
Hospital Besançon -
A. Pavot
Hopital de Bicetre -
C. Goujard
Universite Paris-Saclay -
M. Frémond
Hôpital Necker Enfants Malades, Université de Paris -
E. Carter
Medical Research Council -
A. Rothenbuhler
Universite Paris-Saclay -
A. Linglart
Universite Paris-Saclay -
B. Mignot
Centre Hospitalier Universitaire de Besançon -
A. Comte
Centre Hospitalier Universitaire de Besançon -
N. Cheikh
Centre Hospitalier Universitaire de Besançon -
O. Hermine
Université de Paris, Université de Paris -
L. Breivik
Universitetet i Bergen -
E. Husebye
Universitetet i Bergen, Helse Bergen Haukeland University Hospital, Karolinska Institutet -
S. Humbert
Hospital Besançon -
P. Rohrlich
Centre Hospitalier Universitaire de Nice -
A. Coaquette
Hospital Besançon -
F. Vuoto
University Hospital of Lille -
K. Faure
University Hospital of Lille -
N. Mahlaoui
Hôpital Necker Enfants Malades, Hôpital Necker Enfants Malades -
P. Kotnik
Univerza v Ljubljani Medicinska Fakulteta, University Children's Hospital, Ljubljana -
T. Battelino
Univerza v Ljubljani Medicinska Fakulteta, University Children's Hospital, Ljubljana -
K. Trebušak Podkrajšek
Univerza v Ljubljani Medicinska Fakulteta, University Children's Hospital, Ljubljana -
K. Kisand
Tartu Ülikool -
E. Ferré
National Institute of Allergy and Infectious Diseases (NIAID) -
T. DiMaggio
National Institute of Allergy and Infectious Diseases (NIAID) -
L. Rosen
National Institute of Allergy and Infectious Diseases (NIAID) -
P. Burbelo
National Institute of Dental and Craniofacial Research (NIDCR) -
M. McIntyre
Royal Alexandra Hospital -
N. Kann
Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology -
A. Shcherbina
Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology -
M. Pavlova
Sechenov First Moscow State Medical University -
A. Kolodkina
Endocrinology Research Centre -
S. Holland
National Institute of Allergy and Infectious Diseases (NIAID) -
S. Zhang
Hôpital Necker Enfants Malades, Université de Paris, Rockefeller University -
Y. Crow
Université de Paris, Medical Research Council -
L. Notarangelo
National Institute of Allergy and Infectious Diseases (NIAID) -
H. Su
National Institute of Allergy and Infectious Diseases (NIAID) -
L. Abel
Hôpital Necker Enfants Malades, Université de Paris, Rockefeller University -
M. Anderson
University of California, San Francisco -
E. Jouanguy
Hôpital Necker Enfants Malades, Université de Paris, Rockefeller University -
B. Neven
Université de Paris, Hôpital Necker Enfants Malades -
A. Puel
Hôpital Necker Enfants Malades, Université de Paris, Rockefeller University -
J. Casanova
Hôpital Necker Enfants Malades, Université de Paris, Rockefeller University, Howard Hughes Medical Institute -
M. Lionakis
National Institute of Allergy and Infectious Diseases (NIAID)
Название журнала
- The Journal of experimental medicine
Том
- 218
Выпуск
- 7
Финансирующая организация
- National Institute of Allergy and Infectious Diseases
Номер гранта
- R01 AI088364
Тип документа
- journal article
Тип лицензии Creative Commons
- CC BY
Правовой статус документа
- Свободная лицензия
Источник
- scopus
