Temporal clinical and laboratory response to interleukin-6 receptor blockade with tocilizumab in 89 hospitalized patients with covid-19 pneumonia

D. Fomina; M. Lysenko; I. Beloglazova; Z. Mutovina; N. Poteshkina; I. Samsonova; T. Kruglova; A. Chernov; A. Karaulov

Статья

Temporal clinical and laboratory response to interleukin-6 receptor blockade with tocilizumab in 89 hospitalized patients with covid-19 pneumonia

D. Fomina, M. Lysenko, I. Beloglazova, Z. Mutovina, N. Poteshkina, I. Samsonova, T. Kruglova, A. Chernov, A. Karaulov,

2021

https://doi.org/10.20411/pai.v5i1.392

Background: Pandemic COVID-19 pneumonia due to SARS-2 is an important cause of morbidi-ty and mortality. Emerging evidence links poor outcomes to an inflammatory cytokine storm. Methods: We treated 89 hospitalized patients with COVID-19 pneumonia and heightened systemic inflammation (elevated serum C reactive protein and interleukin-6 levels) with an infusion of tocilizumab (TCZ), a human monoclonal IgG1 antibody to the interleukin-6 receptor. Results: Clinical and laboratory evidence of improvement was evident when baseline and 1-2-day post-infusion indices were compared. Among the 72 patients receiving supplemental oxygen without mechanical ventilation, severity of condition on the NEWS2 scale scores fell from 5 to 2 (P

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1. Version of Record от 2021-04-27

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Об авторах

D. Fomina
City Clinical Hospital No.52 of Moscow Healthcare Department, Moscow, Russian Federation
M. Lysenko
First Sechenov Moscow State Medical University of the Ministry of Healthcare of the Russian Federation, Moscow, Russian Federation
I. Beloglazova
Department of General Therapy, Pirogov Russian National Research Medical University (RNRMU) of the Ministry of Healthcare, Moscow, Russian Federation
Z. Mutovina
Department of General Therapy, Cardiology, and Functional Diagnostics, Federal State Institution of Additional Professional Education “Central State Medical Academy” of the President of the Russian Federation, Moscow, Russian Federation
N. Poteshkina
Research Institute of Molecular and Personalized Medicine, Russian Medical Academy of Continuing Professional Education, Moscow, Russian Federation
I. Samsonova
T. Kruglova
A. Chernov
A. Karaulov

Название журнала

Pathogens and Immunity

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327-341

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Case Western Reserve University

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journal article

Тип лицензии Creative Commons

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Свободная лицензия

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scopus

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Статья

Temporal clinical and laboratory response to interleukin-6 receptor blockade with tocilizumab in 89 hospitalized patients with covid-19 pneumonia

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