Поиск по репозиторию
Статья
Immunological imprint of COVID-19 on human peripheral blood leukocyte populations
2021
Background: SARS-CoV-2 has triggered a pandemic that is now claiming many lives. Several studies have investigated cellular immune responses in COVID-19-infected patients during disease but little is known regarding a possible protracted impact of COVID-19 on the adaptive and innate immune system in COVID-19 convalescent patients. Methods: We used multiparametric flow cytometry to analyze whole peripheral blood samples and determined SARS-CoV-2-specific antibody levels against the S-protein, its RBD-subunit, and viral nucleocapsid in a cohort of COVID-19 convalescent patients who had mild disease ~10 weeks after infection (n = 109) and healthy control subjects (n = 98). Furthermore, we correlated immunological changes with clinical and demographic parameters. Results: Even ten weeks after disease COVID-19 convalescent patients had fewer neutrophils, while their cytotoxic CD8 T cells were activated, reflected as higher HLA-DR and CD38 expression. Multiparametric regression analyses showed that in COVID-19-infected patients both CD3 CD4 and CD3 CD8 effector memory cells were higher, while CD25 Foxp3 T regulatory cells were lower. In addition, both transitional B cell and plasmablast levels were significantly elevated in COVID-19-infected patients. Fever (duration, level) correlated with numbers of central memory CD4 T cells and anti-S and anti-RBD, but not anti-NC antibody levels. Moreover, a “young immunological age” as determined by numbers of CD3 CD45RA CD62L CD31 recent thymic emigrants was associated with a loss of sense of taste and/or smell. Conclusion: Acute SARS-CoV-2 infection leaves protracted beneficial (ie, activation of T cells) and potentially harmful (ie, reduction of neutrophils) imprints in the cellular immune system in addition to induction of specific antibody responses. + + + + + + + + + + + +
Цитирование
Похожие публикации
Версии
- 1. Version of Record от 2021-03-01
Метаданные
Название журнала
- Allergy: European Journal of Allergy and Clinical Immunology
Том
- 76
Выпуск
- 3
Страницы
- 751-765
Финансирующая организация
- Austrian Science Fund
Номер гранта
- COVID001
Тип документа
- journal article
Тип лицензии Creative Commons
- CC BY
Правовой статус документа
- Свободная лицензия
Источник
- scopus
