Diseases of young cattle of infectious etiology are the most important problem of cattle breeding. Among these diseases, the greatest economic damage is caused by diseases in calves of the digestive system, collectively called "neonatal diarrhea". Numerous studies carried out in recent years have irrefutably proven that the main role in the occurrence of diarrhea in calves is played by rota-, coronaviruses, less often viral diarrhea-mucosal disease, as well as bacteria from the genus Escherichia (separately or in associations). These infectious agents cause a similar clinical picture of the disease; therefore only laboratory methods (detection of antigen in feces, organs, and tissues of sick or dead animals, as well as antibodies in the blood) are the basis for the diagnosis. Besides, with the help of diagnostic kits, it is possible to determine the presence of immunity to a particular disease and the need for vaccination. The article provides an overview of certified kits and vaccines for the diagnosis and prevention of coronavirus infection in cattle and discusses the benefits of a comprehensive regimen of their use.