A global problem of humankind in 2020 is the provision of medical care to patients with the new coronavirus infection COVID-19. On the background of unsatisfactory results of studies of the effectiveness of existing antiviral drugs, pathogenetic therapy is of particular importance. As a rule, patients with severe forms of COVID-19 suffer from chronic comorbidities, the exacerbation of which is often the leading cause of poor outcome. The purpose of this work is to analyze the clinical practice of using drugs based on succinates (succinic acid salts) in the treatment of severe forms of COVID-19. A retrospective continuous study of treatment regimens in a group of 223patients with severe forms of COVID-19 showed that about 27% of patients received metabolic drugs containing succinate as one of the active components. Main indications for the prescription of drugs were concomitant and background diseases such as ischemic heart disease, decompensation of diabetes mellitus, discirculatory encephalopathy, and asthenia. In this case, Reamberin (detoxifying agent) was used on the average for 4.8 days (from 2 to 11), Remaxol (hepatoprotective agent) for 6.5 days (from 1 to 18), and Cytoflavin (neuroprotective agent) for 5.7 days (from 2 to 10). The expediency of conducting prospective randomized clinical trials of the effectiveness of including succinate-containing drugs in the therapy regimens for patients with severe forms of COVID-19 in order to improve the quality of medical care provided to this category of patients has been established.