Aim. To present the results of work of National Medical Research Center of Treatment and Rehabilitation, reassigned for COVID-19 patients’ treatment during pandemic. Run-up methodology, procedures and working process organization are detailed. Materials and methods. 354 COVID-19 patients were treated from 13.04.2020 to 10.06.2020 [age 59 (4-70) years, 56% women, body mass index 28.5 (24.9-32.2) kg/m ]. Patients were admitted at 8 (6-11) day of sickness. In-hospital stay was 16 (14-20) days. Results. NEWS scale at the day of admittance was 2 (1-4); 2 (1-3) in patients discharged alive and 6 (4-7) in died patients, p=0.0001. So prognostic accuracy of NEWS scale was confirmed as very well (area under ROC-curve = 0.819). 69 patients (19.5%) were treated at intensive care department for 7 (4-13) days. 13 patients died, 11 of them had COVID-19 as direct or indirect cause of death. Total in-hospital mortality was 3.67%, in-hospital mortality of COVID-19 patients - 3.1%. 17 healthcare workers (HCW), contacted with COVID-19 patients were infected (2.67%). 4 HCW, who had no direct contact with patients were also infected and 7 HCW were infected before the first patient was admitted. No one of them died. Conclusion. Complex tasks of healthcare organization during COVID-19 pandemic can be solved quickly with acceptable quality, characterized by low levels of patients; mortality and HCW infection. 2