Increasingly, there is evidence of the association of mineral metabolism with COVID-19, in particular states such as hypocalcaemia, vitamin D deficiency, which may weigh up the course of a new coronavirus infection. Objective. Evaluate the basic parameters of mineral metabolism in patients with COVID-19 of different severity at admission to the hospital. Material and methods. A single-center study was carried out at the Endocrinology Research Centre, Moscow. Analysis of the mineral metabolism parameters, as well as clinical and instrumental assessment of the COVID-19 severity before specific immunotherapy was performed in 60 patients. Results. The frequency of hypocalcemia (according to the level of albumin-adjusted calcium) and vitamin D deficiency/insufficiency in the study group was 36.7 and 95%, respectively. Lower saturation (SpO ) was observed in the subgroup with a lower level of 25(OH)D (p=0.001) and calcium (p=0.002). Patients with severe COVID-19 pneumonia (computer tomography (CT) scan grade 3-4) compared with those with less changes (CT grade 1-2) had significantly lower total calcium and albumin (p