Статья

Phytochemical properties, biological activities and medicinal use of Centaurium erythraea Rafn

N. El Menyiy, F. Guaouguaou, A. El Baaboua, N. El Omari, D. Taha, N. Salhi, M. Shariati, T. Aanniz, T. Benali, G. Zengin, M. El-Shazly, I. Chamkhi, A. Bouyahya,
2021

Ethnopharmacological relevance: Centaurium erythraea is an important medicinal plant in many countries, e.g. Morocco, Algeria, Italy, Spain, Portugal, and countries of Balkan Peninsula. It is used in folk medicine to treat various illnesses. It is also used as an antiapoplectic, anticoagulant, anticholagogue, antipneumonic, hematocathartic, and as a hypotensive agent. Aim of the review: In this review, previous reports on the taxonomy, botanical description, geographic distribution, ethnomedicinal applications, phytochemistry, pharmacological properties, and toxicity of Centaurium erythraea were critically summarized. Materials and methods: Scientific search engines including PubMed, ScienceDirect, SpringerLink, Web of Science, Scopus, Wiley Online, SciFinder, and Google Scholar were consulted to collect data on C. erythraea. The data presented in this work summarized the main reports on C. erythraea phytochemical compounds, ethnomedicinal uses, and pharmacological activities. Results: C. erythraea is used in traditional medicine to treat various diseases such as diabetes, fever, rhinitis, stomach ailments, urinary tract infections, dyspeptic complaints, loss of appetite, and hemorrhoids, and as diuretic. The essential oils and extracts of C. erythraea exhibited numerous biological properties such as antibacterial, antioxidant, antifungal, antileishmanial, anticancer, antidiabetic, anti-inflammatory, insecticidal, diuretic, gastroprotective, hepatoprotective, dermatoprotective, neuroprotective, and inhibitory agent for larval development. Phytochemical characterization of C. erythraea revealed the presence of several classes of secondary metabolites such as xanthonoids, terpenoids, flavonoids, phenolic acids, and fatty acids. Conclusions: Ethnomedicinal studies demonstrated the use of C. erythraea for the treatment of various disorders. Pharmacological reports showed that C. erythraea especially its aerial parts and roots exhibited potent, and beneficial activities. These findings confirmed the link between the traditional medicinal use and the results of the scientific biological experiments. Considering these results, further investigation using diverse in vivo pharmacological assays are strongly recommended to validate the results of its traditional use. Toxicological tests and pharmacokinetic studies are also required to validate the safety and efficacy of C. erythraea and its bioactive contents.

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  • 1. Version of Record от 2021-08-10

Метаданные

Об авторах
  • N. El Menyiy
    Faculté des Sciences Dhar El Mahraz, Université Sidi Mohamed Ben Abdellah
  • F. Guaouguaou
    Ecole Normale Supérieure de Rabat
  • A. El Baaboua
    Faculté des Sciences Tétouan, Universite Abdelmalek Essaadi
  • N. El Omari
    Faculté de Médecine et de Pharmacie de Rabat
  • D. Taha
    Faculté des Sciences Rabat
  • N. Salhi
    Faculté de Médecine et de Pharmacie de Rabat
  • M. Shariati
    Moscow State University of Technologies and Management
  • T. Aanniz
    Université Cadi Ayyad
  • T. Benali
    Faculté de Médecine et de Pharmacie de Rabat
  • G. Zengin
    Selçuk Üniversitesi
  • M. El-Shazly
    Ain Shams University, German University in Cairo
  • I. Chamkhi
    Mohammed VI Polytechnic University, Institut Scientifique
  • A. Bouyahya
    Faculté des Sciences Rabat
Название журнала
  • Journal of Ethnopharmacology
Том
  • 276
Номер гранта
  • undefined
Тип документа
  • journal article
Тип лицензии Creative Commons
  • CC BY
Правовой статус документа
  • Свободная лицензия
Источник
  • scopus