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Статья
Osteogenic and Angiogenic Properties of Heparin as a System for Delivery of Biomolecules for Bone Bioengineering: a Brief Critical Review
2021
Abstract—: The review considers complex, controversial, and individual effects of heparin and its derivatives on the bone and circulatory systems in dependence of the dose, the state of the cells and tissues of the recipient. General data on the anticoagulant activity of heparin and its derivatives are presented; special attention is paid to the effect of heparin on mesenchymal cells and tissues and its role in angiogenesis. We also discuss the ability of heparin to bind osteogenic and angiogenic biomolecules in the context of the development of systems for their delivery and sustained controlled release and propose a schematic representation of the positive and side effects of heparin as a delivery system for biomolecules in tissue engineering.
Цитирование
Похожие публикации
Версии
- 1. Version of Record от 2021-04-01
Метаданные
Название журнала
- Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry
Том
- 15
Выпуск
- 2
Страницы
- 147-152
Финансирующая организация
- Russian Science Foundation
Номер гранта
- 16-15-10031
Тип документа
- journal article
Тип лицензии Creative Commons
- CC BY
Правовой статус документа
- Свободная лицензия
Источник
- scopus
