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Статья
Osteogenic and angiogenic properties of heparin as a system of biomolecule delivery for bone bioengineering: A brief critical review
2021
The review discusses the complex, ambiguous and individual effects of heparin and its derivatives on the bone and circulatory systems, in dependence of the dosage, the state of the cells and tissues of recipients. General data on the anticoagulant activity of heparin and its derivatives are presented; aspects of the effect of heparin on mesenchymal cells and tissues and its role in angiogenesis are considered in details. Particular attention is paid to the ability of heparin to bind osteogenic and angiogenic biomolecules: This is especially important for the development of systems for their delivery and sustained controlled release. A schematic representation of the positive and side effects of heparin as a delivery system for biomolecules in tissue engineering is proposed.
Цитирование
Похожие публикации
Версии
- 1. Version of Record от 2021-01-01
Метаданные
Название журнала
- Biomeditsinskaya Khimiya
Том
- 66
Выпуск
- 6
Страницы
- 431-436
Финансирующая организация
- Russian Science Foundation
Номер гранта
- 16-15-10031
Тип документа
- journal article
Тип лицензии Creative Commons
- CC BY
Правовой статус документа
- Свободная лицензия
Источник
- scopus
