The review describes the pathogenesis of dermatological manifestations of a new multi-organ human disease COVID-19, classifications and clinical manifestations depending on the age and premorbid background of the patient. Often, the first manifestations of the disease are efflorescence, which occurs before the development of the main symptoms of a viral disease during active viremia, and, consequently, the patient's maximum risk to others. Therefore, knowledge of the first symptoms of the disease, the ability to see and correctly interpret dermatological changes is a prerequisite for competent epidemiological work to limit the spread of a potentially dangerous infection.