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Статья
Synthesis and Properties of 1,3-Disubstituted Ureas and Their Isosteric Analogs Containing Polycyclic Fragments: V. 1-(Bicyclo[2.2.1]heptan-2-yl)-3-R- and 1-(1,7,7-Tricyclo[2.2.1]heptan-2-yl)-3-R-ureas
2020
Abstract: A series of 1,3-disubstituted ureas containing a bicyclic lipophilic group ofnatural origin were synthesized by the reactions of bicyclo[2.2.1]heptane-2-ylisocyanate with amines in yields of up to 82% and by the reactions ofbicyclo[2.2.1]heptan-2-amine and 1,7,7-trimethylbicyclo[2.2.1]heptan-2-aminewith 1,1'-carbonyldiimidazole in yields of up to 94%. The synthesized ureas arepotent inhibitors of RNA virus replication and soluble epoxide hydrolase.
Цитирование
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Версии
- 1. Version of Record от 2020-12-01
Метаданные
Название журнала
- Russian Journal of Organic Chemistry
Том
- 56
Выпуск
- 11
Страницы
- 1893-1904
Финансирующая организация
- Russian Foundation for Basic Research
Номер гранта
- 19-33-60024
Тип документа
- journal article
Тип лицензии Creative Commons
- CC BY
Правовой статус документа
- Свободная лицензия
Источник
- scopus
