Organization of post-infection rehabilitation is an urgent problem in the context of a new coronavirus infection pandemic. Algo-rithm for protection of patients and staff is usually described in the literature. At the same time, rehabilitation process is not ana-lyzed. Therefore, experience exchange is advisable. Objective. To summarize the experience of rehabilitation of patients with COVID-19 infection at the intensive care unit of the Skli-fosovsky Research Institute for Emergency Care. Material and methods. The study included 39 patients with COVID-19 infection in severe and extremely severe condition. Mean age was 60 (52; 67.5) years. Mechanical ventilation was required in 14 (35.9%) patients. All patients underwent rehabilitation around the clock. Results. The rehabilitation program was determined for each patient within 48 hours after admission. Rehabilitation measures included positioning (including pron-position), verticalization, mechanotherapy, physiotherapy exercises, breathing exercises, and psychological support. In this manuscript, we describe the organization of rehabilitation and its features. There were 674 physiotherapy exercises (excluding positioning) and 233 physiotherapy procedures. Each patient underwent 2—3 physiotherapy procedures per day. Patients under mechanical ventilation underwent all rehabilitation procedures without any features of toler-ance or effectiveness. Psychological care was required for difficult adaptation to in-hospital conditions, advanced anxiety and im-paired mood. We have developed a guide on stress management for medical staff and effective communication with patients. Conclusion. Organization of the intensive care unit of infectious building at the Sklifosovsky Research Institute for Emergency Care is close to the international recommendations of experts. Specialists have developed the new methods of working with patients.