Russian-Chinese interaction in the Far East covers relations between the two largest world civilizations: Russia and China. One of its most important features is Chinese migration in the Russian Far Eastern (RFE) border region. This article analyzes the role and importance of Chinese migration as an integral component of the Sino-Russian cross-border interactions that has had varied effects over the past century and a half. Chinese migration is an indispensable condition for the emergence and development of cross-border practices in the RFE and the presence and economic activity of Chinese migrants ensures the continued development of forms of cross-border interaction and, in general, the dialogue between the cultures. To substantiate this thesis, systemic and historical-chronological methods are used to analyze a significant amount of factual and statistical material accumulated by historical research in the works of Russian and Chinese historians and social researchers.