In the current crisis conditions caused by the global challenges of the 21st century: globalization, digitalization, and the COVID-19 pandemic, issues of key staff turnover management are of particular importance. The need to rethink existing approaches to staff turnover management, as well as to identify additional reserves for the development of the organizational and economic management mechanism determines the choice of the research topic, its theoretical and applied significance. The purpose of the research is to develop theoretical and methodological foundations and scientific and practical recommendations for the formation of an organizational and economic mechanism for managing staff turnover. For that purpose, the article analyzes the scientific views on the content of staff turnover and identifies its features in modern economic conditions; the factors of staff turnover in the organization are systematized and clarified; the reasons and motives for turnover are identified, that leads it to dismissal. The modern concept of personnel turnover management in the organization is proved; the organizational and economic mechanism of staff turnover management in the organization is developed.