Поиск по репозиторию
Статья
Experimental comparative pharmacokinetics of levofloxacin, triazavirine, and related conjugate
2021
A comparative study of the pharmacokinetics of levofloxacin and triazavirine as well as 2-memyltMo-6-nitro-l,2,4-triazolo[5,l-ñ]-l,2,4-triazine-7(4r)-ide (3S)-(-)-9-fluoro-2,3-dmydro-3-memyl-10-(4-memylpiperazm-l-yl)-7-oxo-7H-pyri e]-l,4-benzoxazine-6-carboxylic acid (conjugate 2) obtained by conjugation of triazavirine and levofloxacin, representing a new class of pharmacological agents, was carried out in experiments on rats. It is established that conjugate 2 in comparison to individual levofloxacin and triazavirine has a higher relative bioavailability and lower rate of elimination, which can lead to improved effectiveness of therapy at reduced dose and frequency of drug administration.
Цитирование
Похожие публикации
Версии
- 1. Version of Record от 2021-04-27
Метаданные
Название журнала
- Eksperimental'naya i Klinicheskaya Farmakologiya
Том
- 78
Выпуск
- 2
Страницы
- 34-38
Ключевые слова
- 2 methylthio 6 nitro l,2,4 triazolo[5,1 n] 1,2,4 triazine 7(4f) ide 9 fluoro 2,3 dihydro 3 methyl 10 (4 methylpiperazin 1 yl) 7 oxo 7h pyridol [1,2,3 e] 1,4 benzoxazine 6 carboxylic acid; antivirus agent; carboxylic acid; levofloxacin; triazavirine; unclassified drug; antiinfective agent; carboxylic acid; levofloxacin; pyrrole derivative; triazavirin; triazine derivative; Article; comparative effectiveness; controlled study; drug bioavailability; drug conjugation; drug elimination; nonhuman; rat; animal; bioavailability; blood; chemistry; comparative study; half life time; intramuscular drug administration; male; Animals; Anti-Infective Agents; Azoles; Biological Availability; Carboxylic Acids; Half-Life; Injections, Intramuscular; Levofloxacin; Male; Rats; Triazines
Издатель
- Izdatel'stvo Meditsina
Тип документа
- journal article
Источник
- scopus
