Статья

Tula virus: A newly detected hantavirus carried by European common voles

A. Plyusnin, O. Vapalahti, H. Lankinen, H. Lehväslaiho, N. Apekina, Y. Myasnikov, H. Kallio-Kokko, H. Henttonen, Å. Lundkvist, M. Brummer-Korvenkontio, I. Gavrilovskaya, A. Vaheri,
2021

A novel hantavirus has been discovered in European common voles, Microtus arvalis and Microtus rossiaemeridionalis. According to sequencing data for the genomic RNA S segment and nucleocapsid protein and data obtained by immunoblotting with a panel of monoclonal antibodies, the virus, designated Tula virus, is a distinct novel member of the genus Hantavirus. Phylogenetic analyses of Tula virus indicate that it is most closely related to Prospect Hill, Puumala, and Muerto Canyon viruses. The results support the view that the evolution of hantaviruses follows that of their primary carriers. Comparison of strains circulating within a local rodent population revealed a genetic drift via accumulation of base substitutions and deletions or insertions. The Tula virus population from individual animals is represented by quasispecies, indicating the potential for rapid evolution of the agent.

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Версии

  • 1. Version of Record от 2021-04-27

Метаданные

Об авторах
  • A. Plyusnin
    Haartman Institute, Department of Virology, Helsinki University, FIN-00014 Helsinki, Finland
  • O. Vapalahti
    Res. Inst. Poliomyelitis Viral E., RU-142782 Moscow, Russian Federation
  • H. Lankinen
    Department of Forest Ecology, Finnish Forest Research Institute, FIN-01301 Vantaa, Finland
  • H. Lehväslaiho
    Department of Defense Microbiology, Swed. Inst. for Infect. Dis. Control, S-10521 Stockholm, Sweden
  • N. Apekina
    Haartman Institute, Department of Virology, Helsinki University, POB 21, FIN-00014 Helsinki, Finland
  • Y. Myasnikov
  • H. Kallio-Kokko
  • H. Henttonen
  • Å. Lundkvist
  • M. Brummer-Korvenkontio
  • I. Gavrilovskaya
  • A. Vaheri
Название журнала
  • Journal of Virology
Том
  • 68
Выпуск
  • 12
Страницы
  • 7833-7839
Ключевые слова
  • article; genetic drift; Hantavirus; nonhuman; priority journal; RNA sequence; virus transmission; vole
Издатель
  • American Society for Microbiology
Тип документа
  • journal article
Источник
  • scopus