COVID-19.рф: ИНФОРМАЦИЯ ПРОТИВ ПАНДЕМИИ

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Статья

Ancient hybridization and strong adaptation to viruses across African vervet monkey populations

H. Svardal, A. Jasinska, C. Apetrei, G. Coppola, Y. Huang, C. Schmitt, B. Jacquelin, V. Ramensky, M. Müller-Trutwin, M. Antonio, G. Weinstock, J. Grobler, K. Dewar, R. Wilson, T. Turner, W. Warren, N. Freimer, M. Nordborg,
2021
https://doi.org/10.1038/ng.3980

Vervet monkeys are among the most widely distributed nonhuman primates, show considerable phenotypic diversity, and have long been an important biomedical model for a variety of human diseases and in vaccine research. Using whole-genome sequencing data from 163 vervets sampled from across Africa and the Caribbean, we find high diversity within and between taxa and clear evidence that taxonomic divergence was reticulate rather than following a simple branching pattern. A scan for diversifying selection across taxa identifies strong and highly polygenic selection signals affecting viral processes. Furthermore, selection scores are elevated in genes whose human orthologs interact with HIV and in genes that show a response to experimental simian immunodeficiency virus (SIV) infection in vervet monkeys but not in rhesus macaques, suggesting that part of the signal reflects taxon-specific adaptation to SIV. © 2017 Nature America, Inc.

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Документы

Источник

Версии

  • 1. Version of Record от 2021-04-27

Метаданные

Об авторах
  • H. Svardal
    Gregor Mendel Institute, Austrian Academy of Sciences, Vienna Biocenter, Austria
  • A. Jasinska
    Center for Neurobehavioral Genetics, University of California, Los Angeles, CA, United States
  • C. Apetrei
    Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland
  • G. Coppola
    Center for Vaccine Research, University of Pittsburgh, Pittsburgh, PA, United States
  • Y. Huang
    Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA, United States
  • C. Schmitt
    Department of Neurology, University of California, Los Angeles, CA, United States
  • B. Jacquelin
    State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
  • V. Ramensky
    Department of Anthropology, Boston University, Boston, MA, United States
  • M. Müller-Trutwin
    Institut Pasteur, Unité HIPER, Paris, France
  • M. Antonio
    Moscow Institute of Physics and Technology, Department of Dolgoprudny, Russian Federation, Russian Federation
  • G. Weinstock
    Medical Research Council, Gambia Unit, Fajara, Gambia
  • J. Grobler
    Jackson Laboratory for Genomic Medicine, Farmington, United States
  • K. Dewar
    Department of Genetics, University of the Free State, Bloemfontein, South Africa
  • R. Wilson
    Department of Human Genetics, McGill University, Montreal, QC, Canada
  • T. Turner
    Department of Anthropology, University of Wisconsin-Milwaukee, Milwaukee, WI, United States
  • W. Warren
    McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MI, United States
  • N. Freimer
    Department of Genetics, University of Cambridge, Cambridge, United Kingdom
  • M. Nordborg
    Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH, United States
Название журнала
  • Nature Genetics
Том
  • 49
Выпуск
  • 12
Страницы
  • 1705-1713
Ключевые слова
  • interferon; nuclear factor I; RAN binding protein 3; RNA polymerase II; spacer DNA; transactivator protein; transcription factor NFIX; unclassified drug; viral protein; A scan; animal experiment; animal model; Article; Chlorocebus; controlled study; diversifying selection; evolutionary adaptation; gene frequency; genetic variability; genome analysis; human; Human immunodeficiency virus; hybridization; innate immunity; molecular phylogeny; multifactorial inheritance; nonhuman; orthology; population; priority journal; simian acquired immunodeficiency syndrome; Simian immunodeficiency virus; species diversity; taxonomic identification; virus cell interaction; whole genome sequencing; adaptation; Africa; animal; blood; CD4+ T lymphocyte; Chlorocebus aethiops; classification; gene expression profiling; gene ontology; gene regulatory network; genetic variation; genetics; host pathogen interaction; hybridization; metabolism; phylogeny; physiology; rhesus monkey; simian acquired immunodeficiency syndrome; Simian immunodeficiency virus; species difference; virology; Adaptation, Physiological; Africa; Animals; CD4-Positive T-Lymphocytes; Cercopithecus aethiops; Gene Expression Profiling; Gene Ontology; Gene Regulatory Networks; Genetic Variation; Host-Pathogen Interactions; Hybridization, Genetic; Macaca mulatta; Phylogeny; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Species Specificity
Издатель
  • Nature Publishing Group
Тип документа
  • journal article
Тип лицензии Creative Commons
  • CC
Правовой статус документа
  • Свободная лицензия
Источник
  • scopus
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