Статья

Label-free sensitive detection of influenza virus using PZT discs with a synthetic sialylglycopolymer receptor layer

A. Erofeev, P. Gorelkin, D. Kolesov, G. Kiselev, E. Dubrovin, I. Yaminsky,
2021

We describe rapid, label-free detection of Influenza A viruses using the first radial mode of oscillations of lead zirconate titanate (PZT) piezoelectric discs with a 2 mm radius and 100 µm thickness fabricated from a piezoelectric membrane. The discs are modified with a synthetic sialylglycopolymer receptor layer, and the coated discs are inserted in a flowing virus suspension. Label-free detection of the virus is achieved by monitoring the disc radial mode resonance frequency shift. Piezo transducers with sialylglycopolymer sensor layers exhibited a long lifetime, a high sensitivity and the possibility of regeneration. We demonstrate positive, label-free detection of Influenza A viruses at concentrations below 105 virus particles per millilitre. We show that label-free, selective, sensitive detection of influenza viruses by home appliances is possible in principle. © 2019 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.

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  • 1. Version of Record от 2021-04-27

Метаданные

Об авторах
  • A. Erofeev
    Lomonosov Moscow State University, 1, Leninskie Gory, Moscow, 119991, Russian Federation
  • P. Gorelkin
    National University of Science and Technology ‘MISIS’, Leninskiy prospect 4, Moscow, 119991, Russian Federation
  • D. Kolesov
    Medical Nanotechnology LLC, Skolkovo, Russian Federation
  • G. Kiselev
    FSBSI, Institute of General Pathology and Pathophysiology, 8, Baltiyskaya st., Moscow, 125315, Russian Federation
  • E. Dubrovin
    Advanced Technologies Center, 4-5-47, Stroiteley Street, Moscow, 119311, Russian Federation
  • I. Yaminsky
Название журнала
  • Royal Society Open Science
Том
  • 6
Выпуск
  • 9
Страницы
  • -
Издатель
  • Royal Society Publishing
Тип документа
  • journal article
Тип лицензии Creative Commons
  • CC
Правовой статус документа
  • Свободная лицензия
Источник
  • scopus